ArticleeLife2014
The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 48 citations in OpenAlex.
- Interactions between the myosin Dachs, the adaptor Dlish, and the palmitoyltransferase Approximated mediate Fat-Dachsous signaling.bioRxiv : the preprint server for biology · 2026Article
- Fat and Dachsous Signaling-Controlling Growth Requires Both Competition and Cooperation: Competitive Interactions at the Cell Cortex Restrict the Ability of an Unusual Protein Complex to Promote Tissue Growth.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling.Nature communications · 2025Article
- Regulation of Hippo signaling and planar cell polarity via distinct regions of the Fat intracellular domain.Development (Cambridge, England) · 2025Article
- The deubiquitylating enzyme Fat facets promotes Fat signalling and restricts tissue growth.Nature communications · 2025Article
- Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.The Journal of cell biology · 2024Article
- Cortical tension promotes Kibra degradation via Par-1.Molecular biology of the cell · 2024Article
- Expanded directly binds conserved regions of Fat to restrain growth via the Hippo pathway.The Journal of cell biology · 2023Article
- Phase separation of Hippo signalling complexes.The EMBO journal · 2023Article
- Distinct mechanisms of planar polarization by the core and Fat-Dachsous planar polarity pathways in the Drosophila wing.Cell reports · 2022Article
- Functional characterization of FBXL7 as a novel player in human cancers.Cell death discovery · 2022Review
- Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins.Frontiers in cell and developmental biology · 2022Review
- Article
- Elucidate growth control mechanisms using reconstructed spatiotemporal distributions of signaling events.Computational and structural biotechnology journal · 2021Article
- miR-152-5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7.Journal of cellular and molecular medicine · 2020Article
- Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome.American journal of medical genetics. Part A · 2020Article
- Transcriptomic Responses to Thermal Stress and Varied Phosphorus Conditions inMicroorganisms · 2019Article
- Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Early girl is a novel component of the Fat signaling pathway.PLoS genetics · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D). Multiple regions of the intracellular domain of Ft have been implicated in regulating growth and PCP but how Ft regulates D is not known. Mutations in Fbxl7, which encodes an F-box protein, result in tissue overgrowth and abnormalities in proximodistal patterning that phenocopy deleting a specific portion of the intracellular domain (ICD) of Ft that regulates both growth and PCP. Fbxl7 binds to this same portion of the Ft ICD, co-localizes with Ft to the proximal edge of cells and regulates the levels and asymmetry of D at the apical membrane. Fbxl7 can also regulate the trafficking of proteins between the apical membrane and intracellular vesicles. Thus Fbxl7 functions in a subset of pathways downstream of Ft and links Ft to D localization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.