ArticleJournal of neuro-oncology2014
Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma.
Article in Journal of neuro-oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Approaches to Minimise the Neurodevelopmental Impact of Choroid Plexus Carcinoma and Its Treatment.Life (Basel, Switzerland) · 2023Review
- Preclinical validation of a novel therapeutic strategy for choroid plexus carcinoma.Journal of controlled release : official journal of the Controlled Release Society · 2023Article
- Durability of an endoscopic management strategy for recurrent choroid plexus carcinoma with a comprehensive molecular characterization: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Primary adult choroid plexus carcinomas: a single-center experience with a systematic review.Frontiers in oncology · 2023Article
- Tumors of Choroid Plexus and Other Ventricular Tumors.Advances in experimental medicine and biology · 2023Article
- Choroid plexus carcinoma in an adolescent male: a case report.Journal of medical case reports · 2021Article
- Late recurrence of choroid plexus carcinoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Management of choroid plexus tumors-an institutional experience.Acta neurochirurgica · 2019Article
- Successful multimodal treatment of a gigantic choroid plexus carcinoma (CPC) in an 8-year-old girl.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Successful Treatment of Recurrent Li-Fraumeni Syndrome-related Choroid Plexus Carcinoma.Journal of pediatric hematology/oncology · 2017Article
- Choroid plexus tumors in adult and pediatric populations: the Cleveland Clinic and University Hospitals experience.Journal of neuro-oncology · 2017Article
- The role of chemotherapy and surgical removal in the treatment of Choroid Plexus carcinomas and atypical papillomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Role of available adjuvant therapies following surgical resection of atypical choroid plexus papilloma-a systematic review and pooled analysis.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Choroid plexus carcinoma (CPCs) is a rare, malignant, primary brain tumor with a poor prognosis. Currently, there is no consensus on the use of adjuvant therapy, and few large-scale studies focus exclusively on the pediatric population. We performed a comprehensive systematic review of pediatric CPCs to determine the effects of various adjuvant therapy modalities on overall survival (OS). A literature search was performed to identify studies reporting children with CPC who underwent surgical resection. Only patients who had clearly received adjuvant therapy, or were described as not selected for adjuvant therapy were analyzed in our comparison groups. Kaplan-Meier and multivariate Cox regression survival analyses were performed to determine the effects of different types of adjuvant therapies on OS. A total of 135 children (age ≤ 18 years) with CPC who had known adjuvant therapy status and OS were identified from 53 articles. Kaplan-Meier analysis showed that while adjuvant therapy overall improved OS (p = 0.001), different modes of adjuvant therapies had varying effects on OS (p = 0.034). Specifically, combined chemo-radiotherapy as well as chemotherapy alone improved OS (p = 0.001), but radiation did not (p = 0.129). Multivariate Cox proportional hazard model adjusting for confounding factors showed that combined therapy was associated with better OS compared to chemotherapy alone (HR: 0.291, p = 0.027). Both chemotherapy alone and combined chemo-radiation improved OS independent of age, gender, tumor location and extent of resection, while radiation alone did not.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.