ArticleGenome biology and evolution2014
Horizontal transfers and gene losses in the phospholipid pathway of bartonella reveal clues about early ecological niches.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
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- Tracking tick-borne diseases in Mongolian livestock using next generation sequencing (NGS).Ticks and tick-borne diseases · 2022Article
- Identification ofThe American journal of tropical medicine and hygiene · 2019Article
- Global fingerprint of humans on the distribution of Bartonella bacteria in mammals.PLoS neglected tropical diseases · 2018Article
- Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis.Clinical microbiology reviews · 2017Review
- Genomic changes associated with the evolutionary transition of an insect gut symbiont into a blood-borne pathogen.The ISME journal · 2017Article
- Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella.Genome biology and evolution · 2017Article
- Phylogenetic and geographic patterns of bartonella host shifts among bat species.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Coexistence of Bartonella henselae and B. clarridgeiae in populations of cats and their fleas in Guatemala.Journal of vector ecology : journal of the Society for Vector Ecology · 2015Article
- Found and Lost: The Fates of Horizontally Acquired Genes in Arthropod-Symbiotic Spiroplasma.Genome biology and evolution · 2015Article
- Classification of Bartonella strains associated with straw-colored fruit bats (Eidolon helvum) across Africa using a multi-locus sequence typing platform.PLoS neglected tropical diseases · 2015Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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Abstract
Bartonellae are mammalian pathogens vectored by blood-feeding arthropods. Although of increasing medical importance, little is known about their ecological past, and host associations are underexplored. Previous studies suggest an influence of horizontal gene transfers in ecological niche colonization by acquisition of host pathogenicity genes. We here expand these analyses to metabolic pathways of 28 Bartonella genomes, and experimentally explore the distribution of bartonellae in 21 species of blood-feeding arthropods. Across genomes, repeated gene losses and horizontal gains in the phospholipid pathway were found. The evolutionary timing of these patterns suggests functional consequences likely leading to an early intracellular lifestyle for stem bartonellae. Comparative phylogenomic analyses discover three independent lineage-specific reacquisitions of a core metabolic gene-NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (gpsA)-from Gammaproteobacteria and Epsilonproteobacteria. Transferred genes are significantly closely related to invertebrate Arsenophonus-, and Serratia-like endosymbionts, and mammalian Helicobacter-like pathogens, supporting a cellular association with arthropods and mammals at the base of extant Bartonella spp. Our studies suggest that the horizontal reacquisitions had a key impact on bartonellae lineage specific ecological and functional evolution.
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