ArticleAnnals of clinical microbiology and antimicrobials2014
Type II and type IV topoisomerase mutations in clinical isolates of Morganella morganii harbouring the qnrD gene.
Article in Annals of clinical microbiology and antimicrobials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A systematic review and meta-analysis of the global prevalence of fluoroquinolone resistant Morganella morganii clinical isolates.Scientific reports · 2025Pooled it
- Draft genome sequence of emerging pathogenMicrobiology resource announcements · 2025Article
- Genomic insights into a Proteus mirabilis strain inducing avian cellulitis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- A Genomic and Bioinformatics View of the Classification and Evolution ofMicrobiology spectrum · 2022Article
- Prevalence of extended spectrum beta lactamase and plasmid mediated quinolone resistant genes in strains ofPeerJ · 2018Article
- Characterization and Comparative Overview of Complete Sequences of the First Plasmids ofFrontiers in microbiology · 2016Article
- Draft Genomic Analysis of an Avian Multidrug ResistantFrontiers in microbiology · 2016Article
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to show the emergence of the qnrD gene among fluoroquinolone-resistant Morganella morganii isolate. The occurrence of mutations in DNA gyrase (gyrA and gyrB) and topoisomerase IV (parC,parE) genes was also investigated in this strain. METHODOLOGY: 95 clinical Enterobacteria were screened for harbouring the qnrD gene. The clinical isolate of M. morganii was recovered from urine from a patient hospitalized in the urology unit at Fattouma Bourguiba Hospital, Tunisia. Antibiotic susceptibility was tested with the agar disk diffusion method. Quinolone susceptibility was studied with microbroth dilution technique. The investigations of plasmid mediated quinolone resistance (PMQR) and topoisomerases mutations were performed by polymerase chain reaction and nucleotide sequencing.
resultsThis isolate showed high level of resistance to quinolones. The MIC with microbroth dilution technique was 512 μg/ml for norfloxacin, 256 μg/ml for ofloxacin and ciprofloxacin and 64μg/ml for levofloxacin.This strain was found to harbour the quinolone resistance determinant qnrD. In addition, this strain harboured two new gyrB mutations (S463A, S464Y) and one parC mutation (S80I).
conclusionsThis is the first report in Tunisia of qnrD determinant and tow new gyrB muations in M. morganii. The nosocomial infection due to this proteeae invites further study of its epidemiologic evolution.
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