ArticleEuropean journal of nuclear medicine and molecular imaging2014
Performance of intra-procedural 18-fluorodeoxyglucose PET/CT-guided biopsies for lesions suspected of malignancy but poorly visualized with other modalities.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Diagnostic Efficacy of PET/CT-Aided versus Conventional CT-guided Lung Biopsy: A Systematic Review and Meta-AnalysisCurrent medical imaging · 2025Pooled it
- [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Trial
- Comparison of CT and PET/CT for biopsy guidance in oncological patients.European journal of nuclear medicine and molecular imaging · 2017Trial
- Performance of image-guided bone biopsies in malignant lesions: impact of PET/CT metabolic activity on the number of samples required.Insights into imaging · 2025Article
- The Efficacy of PET/CT Scan in CT-Guided Needle Biopsy of Large Lung Mass.Respirology case reports · 2025Article
- Augmenting CT-Guided Bone Biopsies UsingCancers · 2024Article
- Clinical Role of Upfront F-18 FDG PET/CT in Determining Biopsy Sites for Lung Cancer Diagnosis.Diagnostics (Basel, Switzerland) · 2024Article
- Advancements and Future Outlook of PET/CT-Guided Interventions.Techniques in vascular and interventional radiology · 2023Review
- Imaging in Interventional Radiology: 2043 and Beyond.Radiology · 2023Review
- Recent progress in the imaging of c-Met aberrant cancers with positron emission tomography.Medicinal research reviews · 2022Review
- Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2022Article
- Practice and prospects for PET/CT guided interventions.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2021Review
- A case series on the role ofEuropean journal of hybrid imaging · 2021Article
- A Diagnostic Nomogram Based onFrontiers in cell and developmental biology · 2021Article
- Comparison Between CBCT and Fusion PET/CT-CBCT Guidance for Lung Biopsies.Cardiovascular and interventional radiology · 2021Observational
- Diagnostic accuracy of positron emission tomography/computed tomography-driven biopsy for the diagnosis of lymphoma.European journal of nuclear medicine and molecular imaging · 2020Article
- A Retrospective Study of predicting risk of Metastasis among FDG-avid Bone Lesions inJournal of Cancer · 2020Article
- Lung and Abdominal Biopsies in the Age of Precision Medicine.Seminars in interventional radiology · 2019Review
- Initial experience with dual-energy computed tomography-guided bone biopsies of bone lesions that are occult on monoenergetic CT.Skeletal radiology · 2019Article
- Is it sufficient to evaluate bone marrow involvement in newly diagnosed lymphomas usingBMC cancer · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe sought to evaluate the safety and the diagnostic success rate of percutaneous biopsies performed under intra-procedural (18)F-deoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT) guidance for lesions difficult to see with conventional cross-sectional imaging.
methodsFrom 2011 to 2013, consecutive clinically indicated percutaneous PET/CT-guided biopsies of 106 masses (mean size, 3.3 cm; range, 0.7-15.9 cm; SD, 2.9 cm) in bones (n = 33), liver (n = 26), soft tissues (n = 18), lung (n = 15) and abdomen (n = 14) were reviewed. The biopsy procedures were performed following injection of a mean of 255 MBq (SD, 74) FDG. Mean maximal standardized uptake value (SUV) of lesions was 8.8 (SD, 6.3). A systematic review of the histopathological results and outcomes was performed.
resultsBiopsies were positive for malignancy in 76 cases (71.7%, 76/106) and for benign tissue in 30 cases (28.3%, 30/106). Immediate results were considered adequate for 100 PET/CT biopsies (94.3%, 100/106) requiring no further exploration, and for the six others (5.7%, 6/106) benign diagnoses were confirmed after surgery (n = 4) or follow-up (n = 2). The consequent overall sensitivity and the diagnostic success of biopsy were therefore 100%. No significant differences in terms of detection of malignancy were observed between the different locations. Lesions > 2 cm or with SUV > 4 were not significantly more likely to be malignant. Complications occurred after four biopsies (3.7%, 4/106).
conclusionIntra-procedural PET/CT guidance appears as a safe and effective method and allows high diagnostic success of percutaneous biopsies for metabolically active lesions.
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