Evidence map›Paper›PMID 25106429›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2014

TRIM72 is required for effective repair of alveolar epithelial cell wounding.

Seong Chul Kim, Thomas Kellett, Shaohua Wang, Miyuki Nishi, Nagaraja Nagre, Beiyun Zhou, Per Flodby, Konstantin Shilo, Samir N Ghadiali, Hiroshi Takeshima and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Anti-TRIM72 Autoantibodies in Idiopathic Inflammatory Myopathies.medRxiv : the preprint server for health sciences · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Is MG53 a potential therapeutic target for cancer?Frontiers in endocrinology · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seong Chul KimDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio;
Thomas KellettDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio;
Shaohua WangThoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota;
Miyuki NishiDepartment of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan;
Nagaraja NagreDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio;
Beiyun ZhouWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, University of Southern California, Los Angeles, California;
Per FlodbyWill Rogers Institute Pulmonary Research Center, Division of Pulmonary, Critical Care and Sleep Medicine, University of Southern California, Los Angeles, California;
Konstantin ShiloThoracic Pathology Division, Department of Pathology, The Ohio State University, Columbus, Ohio;
Samir N GhadialiBiomedical Engineering Department, College of Engineering, The Ohio State University, Columbus, Ohio; and.
Hiroshi TakeshimaDepartment of Biological Chemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan;
Rolf D HubmayrThoracic Diseases Research Unit, Mayo Clinic, Rochester, Minnesota;
Xiaoli ZhaoDivision of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, College of Medicine, The Ohio State University, Columbus, Ohio zhao.1028@osu.edu.

Funding

Targeting Membrane Repair in Deformation-Induced Lung InjuryR01HL116826 · NHLBI · OHIO STATE UNIVERSITY · PI ZHAO, XIAOLI · 2013 to 2017
$1.9M
NHLBI NIH HHS R01 HL116826NHLBI NIH HHS R01HL116826
6 · The paper itself

Abstract

The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and linked its function to tissue repair. In this study, we characterized TRIM72 expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. In vivo injury of lung cells was introduced by high tidal volume ventilation, and repair-defective cells were labeled with postinjury administration of propidium iodide. Primary alveolar epithelial cells were isolated and membrane wounding and repair were labeled separately. Our results show that absence of TRIM72 increases susceptibility to deformation-induced lung injury whereas TRIM72 overexpression is protective. In vitro cell wounding assay revealed that TRIM72 protects alveolar epithelial cells through promoting repair rather than increasing resistance to injury. The repair function of TRIM72 in lung cells is further linked to caveolin 1. These data suggest an essential role for TRIM72 in repair of alveolar epithelial cells under plasma membrane stress failure.

Indexed as

Epithelial CellsPulmonary AlveoliWound HealingAnimalsCarrier ProteinsCaveolin 1Cell MembraneCells, CulturedMembrane ProteinsMiceMice, KnockoutCarrier ProteinsCav1 protein, mouseCaveolin 1Membrane ProteinsMG53 protein, mouseacute lung injuryalveolar epithelial cellscaveolin 1plasma membrane wounding and repairtripartite motif protein 72

Identifiers

PMID25106429
PMCPMC4166787

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.