ReviewCurrent opinion in endocrinology, diabetes, and obesity2014
Weight loss and bone mineral density.
Review in Current opinion in endocrinology, diabetes, and obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07094568 (Comparative Investigation of Changes in Body Composition and Bone Turnover Markers in People With Obesity After Treatment With Tirzepatide Versus Liraglutide. A Prospective Cohort Study.), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Investigation of Changes in Body Composition and Bone Turnover Markers in People With Obesity After Treatment With Tirzepatide Versus Liraglutide. A Prospective Cohort Study.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of exercise training and dietary supplement on fat free mass and bone mass density during weight loss - a systematic review and meta-analysis.F1000Research · 2022Pooled it
- Effects of a Plant-Based Multi-StrainNutrients · 2026Trial
- Sex Hormones Mediate Intensive Lifestyle Intervention-Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study.The Journal of clinical endocrinology and metabolism · 2026Trial
- Genetically determined SCFA concentration modifies the association of dietary fiber intake with changes in bone mineral density during weight loss: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.The American journal of clinical nutrition · 2021Trial
- Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults.Nutrients · 2021Trial
- Genetically determined vitamin D levels and change in bone density during a weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS Lost) Trial.The American journal of clinical nutrition · 2018Trial
- Commercially available lifestyle modification program: randomized controlled trial addressing heart and bone health in BRCA1/2+ breast cancer survivors after risk-reducing salpingo-oophorectomy.Journal of cancer survivorship : research and practice · 2017Trial
- Serum Bone-, Muscle- and Fat- Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross-Sectional Study.Diabetes/metabolism research and reviews · 2026Article
- Article
- Weight loss lifestyle intervention and bone health hormonal markers in type 2 diabetes: analysis from look AHEAD study.Journal of the Endocrine Society · 2026Article
- Effects of a Combined Dietary and Physical Activity Intervention on Bone Density, Lean Mass and Fat Mass in Adults: The GOTO Trial.Journal of cachexia, sarcopenia and muscle · 2026Article
- Treatment Decision-making and Weight Loss Expectations for Current Obesity Treatment.Current obesity reports · 2026Review
- Obesity and healthy aging: fat, muscle, and bone trade-offs in an era of potent weight-loss pharmacotherapy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- 20% Caloric Restriction did not Impact Bone Health nor Exercise-Induced Elevations in Bone Mass in Young Female Rats.Calcified tissue international · 2026Article
- Obesity: assessment and treatment across the care continuum.Annals of medicine · 2025Review
- Beyond Weight Loss: Optimizing GLP-1 Receptor Agonist Use in Children.Children (Basel, Switzerland) · 2025Review
- The effects of 12 weeks of plyometric training on body composition, physical strength, and bone mineral density in obese adolescents.Journal of exercise rehabilitation · 2025Article
- Review
- Factors associated with bone health in long distance runners: a cross-sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Chronicity of obesity and the importance of early treatment to reduce cardiometabolic risk and improve body composition.Obesity pillars · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purpose of reviewDespite evidence that energy deficit produces multiple physiological and metabolic benefits, clinicians are often reluctant to prescribe weight loss in older individuals or those with low bone mineral density (BMD), fearing BMD will be decreased. Confusion exists concerning the effects that weight loss has on bone health. RECENT
findingsBone density is more closely associated with lean mass than total body mass and fat mass. Although rapid or large weight loss is often associated with loss of bone density, slower or smaller weight loss is much less apt to adversely affect BMD, especially when it is accompanied with high intensity resistance and/or impact loading training. Maintenance of calcium and vitamin D intake seems to positively affect BMD during weight loss. Although dual energy X-ray absorptiometry is normally used to evaluate bone density, it may overestimate BMD loss following massive weight loss. Volumetric quantitative computed tomography may be more accurate for tracking bone density changes following large weight loss. SUMMARY: Moderate weight loss does not necessarily compromise bone health, especially when exercise training is involved. Training strategies that include heavy resistance training and high impact loading that occur with jump training may be especially productive in maintaining, or even increasing bone density with weight loss.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.