ArticleMolecules (Basel, Switzerland)2014
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
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- Allocryptopine, tetrahydropalmatine, and tetrahydroberberine N-oxide alkaloids alleviate cellular stress by modulating calcium homeostasis and the MAPK and akt/GSK-3β/tau signaling pathways.Frontiers in pharmacology · 2025Article
- Structural Characterization and In Vitro Anti-Inflammatory Activity of Polysaccharides Isolated from the Fruits ofInternational journal of molecular sciences · 2024Article
- Modulation of Cytoskeleton, Protein Trafficking, and Signaling Pathways by Metabolites fromPharmaceuticals (Basel, Switzerland) · 2022Review
- Gabapentin Alleviates Brain Injury in Intracerebral Hemorrhage Through Suppressing Neuroinflammation and Apoptosis.Neurochemical research · 2022Article
- Chemical constituents and pharmacological activities of medicinal plants fromChinese herbal medicines · 2022Review
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- Traditional uses, phytochemical, pharmacology, quality control and modern applications of two important Chinese medicines fromFrontiers in pharmacology · 2022Review
- Soybean Whey Bio-Processed UsingFrontiers in nutrition · 2022Article
- Rosanortriterpenes A-B, Two Promising Agents fromEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Hydroxy-Oxidative medicine and cellular longevity · 2020Article
- Effect ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Correction: Liu, M., et al. Potent Effects of Flavonoid-Rich Extract fromMolecules (Basel, Switzerland) · 2019Article
- Gynura bicolor aqueous extract attenuated HBioMedicine · 2019Article
- The Protective Effect of the Total Flavonoids ofOxidative medicine and cellular longevity · 2018Article
- Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts.Molecules (Basel, Switzerland) · 2017Article
- Therapeutic Applications of Rose Hips from Different Rosa Species.International journal of molecular sciences · 2017Review
- Esculetin Neutralises Cytotoxicity ofBioMed research international · 2017Article
- The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain.Oxidative medicine and cellular longevity · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress-induced neuronal death has an important role in the pathogenesis of neurodegenerative disorders. The effects and mechanisms of action of the total flavonoids (TFs) from Rosa laevigata Michx fruit against hydrogen peroxide (H2O2)-induced oxidative injury in PC12 cells were investigated in this study. The results demonstrated that the TFs protected against cell apoptosis, DNA and mitochondrial damage caused by H2O2 based on single cell gel electrophoresis, in situ terminal deoxynucleotidyltransferase dUTP nick end labeling (TUNEL), flow cytometry and transmission electron microscope (TEM) assays. In addition, the TFs notably decreased cytochrome C release from mitochondria into the cytosol and intracellular Ca2+ levels, and diminished intracellular generation of reactive oxygen species (ROS). Furthermore, the TFs inhibited the phosphorylation levels of JNK, ERK and p38 MAPK as well as down-regulated the expressions of IL-1, IL-6, TNF-α, Fas, FasL, CYP2E1, Bak, caspase-3, caspase-9, p53, COX-2, NF-κB, AP-1, and up-regulated the expressions of Bcl-2 and Bcl-xl. In conclusion, these results suggest that the TFs from R. laevigata Michx fruit show good effects against H2O2-induced oxidative injury in PC12 cells by adjusting oxidative stress, and suppression of apoptosis and inflammation, and could be developed as a potential candidate to prevent oxidative stress in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.