Evidence map›Paper›PMID 25105800›Full record

ArticlePloS one2014

Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury.

Marcus K Giacci, Lachlan Wheeler, Sarah Lovett, Emma Dishington, Bernadette Majda, Carole A Bartlett, Emma Thornton, Elizabeth Harford-Wright, Anna Leonard, Robert Vink and 8 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Review
  7. Article
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  12. Inhibiting Mitochondrial CytochromeFrontiers in physiology · 2021
    Article
  13. Article
  14. Safety Profile of Slit-Lamp-Delivered Retinal Laser Photobiomodulation.Translational vision science & technology · 2020
    Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Marcus K GiacciExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Animal Biology, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Lachlan WheelerExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Sarah LovettExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Emma DishingtonExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Bernadette MajdaExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Carole A BartlettExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Animal Biology, The University of Western Australia, Crawley, Australia.
Emma ThorntonSchool of Medical Sciences, The University of Adelaide, Adelaide, Australia.
Elizabeth Harford-WrightSchool of Medical Sciences, The University of Adelaide, Adelaide, Australia.
Anna LeonardSchool of Medical Sciences, The University of Adelaide, Adelaide, Australia.
Robert VinkSchool of Medical Sciences, The University of Adelaide, Adelaide, Australia.
Alan R HarveyExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Jan ProvisANU Medical School and John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Sarah A DunlopExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Animal Biology, The University of Western Australia, Crawley, Australia.
Nathan S HartSchool of Animal Biology, The University of Western Australia, Crawley, Australia; Neuroecology Group, The Oceans Institute, The University of Western Australia, Crawley, Australia.
Stuart HodgettsExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Anatomy, Physiology and Human Biology, The University of Western Australia, Crawley, Australia.
Riccardo NatoliANU Medical School and John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Corinna Van Den HeuvelSchool of Medical Sciences, The University of Adelaide, Adelaide, Australia.
Melinda FitzgeraldExperimental and Regenerative Neurosciences, The University of Western Australia, Crawley, Australia; School of Animal Biology, The University of Western Australia, Crawley, Australia.
University of Western Australia · AUUniversity of Adelaide · AUAustralian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hampered by lack of comparative information regarding the degree of penetration of the delivered irradiation to the injury site and the optimal treatment parameters for different CNS injuries. We compared the treatment efficacy of R/NIR-IT at 670 nm and 830 nm, provided by narrow-band LED arrays adjusted to produce equal irradiance, in four in vivo rat models of CNS injury: partial optic nerve transection, light-induced retinal degeneration, traumatic brain injury (TBI) and spinal cord injury (SCI). The number of photons of 670 nm or 830 nm light reaching the SCI injury site was 6.6% and 11.3% of emitted light respectively. Treatment of rats with 670 nm R/NIR-IT following partial optic nerve transection significantly increased the number of visual responses at 7 days after injury (P ≤ 0.05); 830 nm R/NIR-IT was partially effective. 670 nm R/NIR-IT also significantly reduced reactive species and both 670 nm and 830 nm R/NIR-IT reduced hydroxynonenal immunoreactivity (P ≤ 0.05) in this model. Pre-treatment of light-induced retinal degeneration with 670 nm R/NIR-IT significantly reduced the number of Tunel+ cells and 8-hydroxyguanosine immunoreactivity (P ≤ 0.05); outcomes in 830 nm R/NIR-IT treated animals were not significantly different to controls. Treatment of fluid-percussion TBI with 670 nm or 830 nm R/NIR-IT did not result in improvements in motor or sensory function or lesion size at 7 days (P>0.05). Similarly, treatment of contusive SCI with 670 nm or 830 nm R/NIR-IT did not result in significant improvements in functional recovery or reduced cyst size at 28 days (P>0.05). Outcomes from this comparative study indicate that it will be necessary to optimise delivery devices, wavelength, intensity and duration of R/NIR-IT individually for different CNS injury types.

Indexed as

AnimalsBrainBrain InjuriesFemaleInfrared RaysMaleOptic NerveOptic Nerve InjuriesRats, Sprague-DawleyRetinaRetinal DegenerationSpinal CordSpinal Cord Injuries

Identifiers

PMID25105800
PMCPMC4126771
OpenAlexW2052760236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.