Evidence map›Paper›PMID 25105575›Full record

ArticleCell stem cell2014

Another brick in the wall: RNAi Screens identify new barriers in iPSC reprogramming.

Maria Winzi, Maciej Paszkowski-Rogacz, Frank Buchholz

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Maria WinziUniversity Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, Germany.
Maciej Paszkowski-RogaczUniversity Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, Germany.
Frank BuchholzUniversity Hospital and Medical Faculty Carl Gustav Carus, UCC, Medical Systems Biology, Technische Universität Dresden, 01307 Dresden, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. Electronic address: frank.buchholz@tu-dresden.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic cells can be reprogrammed to induced pluripotent stem cells via exogenous expression of a small set of transcription factors, but the regulatory mechanisms controlling this cell transition are poorly understood. Two recent reports demonstrate the value of RNAi screens as a tool to uncover roadblocks in this inefficient process.

Indexed as

Cellular ReprogrammingHumansInduced Pluripotent Stem Cells

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.