ArticleNature communications2014
General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
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- Dimeric Transmembrane Structure of the SARS-CoV-2 E Protein.Communications biology · 2023Article
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- Toward a Model for Activation of Orai Channel.iScience · 2019Article
- Exploring conformational states and helical packings in the P2X receptor transmembrane domain by molecular dynamics simulation.Journal of biological physics · 2018Article
- Structural modeling for the open state of an NMDA receptor.Journal of structural biology · 2017Article
- Joint-based description of protein structure: its application to the geometric characterization of membrane proteins.Scientific reports · 2017Article
- Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.Trends in neurosciences · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
The pore-lining helix (PLH) bundles are central to the function of all ion channels, as their conformational rearrangements dictate channel gating. Here we explore all plausible oligomeric arrangements of the PLH bundles within homomeric ion channels by building models using generic restraints. In particular, the distance between two neighbouring PLHs was bounded both below and above in order to avoid steric clash and allow proper packing. The resulting models provide a theoretical representation of the accessible space for oligomeric arrangements. While the represented space is confined, it encompasses nearly all the ion channel PLH bundles for which the structures are currently known. For a multitude of channels, gating models suggested by paths within the confined accessible space are in qualitative agreement with those established in previous structural and computational studies.
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