Evidence map›Paper›PMID 25105535›Full record

Trial reportBlood cancer journal2014

Immune regulatory effects of panobinostat in patients with Hodgkin lymphoma through modulation of serum cytokine levels and T-cell PD1 expression.

Y Oki, D Buglio, J Zhang, Y Ying, S Zhou, A Sureda, D Ben-Yehuda, P L Zinzani, H M Prince, S J Harrison and 5 more

Open access · goldAbstract readClinical Trial, Phase IILetterMulticenter Study
In one paragraph

Trial report in Blood cancer journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 61 citations in OpenAlex.

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  17. Recent Update of HDAC Inhibitors in Lymphoma.Frontiers in cell and developmental biology · 2020
    Review
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  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 7 countries.

Y OkiDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
D BuglioDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
J ZhangDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Y YingDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
S ZhouDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
A SuredaHematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
D Ben-YehudaHematology Division, Hadassah Medical Organization, Jerusalem, Israel.
P L ZinzaniInstitute of Hematology and Medical Oncology, University of Bologna, Bologna, Italy.
H M PrincePeter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia.
S J HarrisonPeter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria, Australia.
M KirschbaumDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.
P B JohnstonDepartment of Hematology, Mayo Clinic, Rochester, MN, USA.
A ShenNovartis Pharmaceuticals, Florham Park, NJ, USA.
B von TresckowUniversity Hospital of Cologne, Cologne, Germany.
A YounesDepartment of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USUniversity of Melbourne · AUCity Of Hope National Medical Center · USHadassah Medical Center · ILHospital de Sant Pau · ESMayo Clinic in Arizona · USNovartis (United States) · USUniversity of Bologna · ITUniversity of Cologne · DE

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CytokinesGene Expression Regulation, NeoplasticHodgkin DiseaseNeoplasm ProteinsProgrammed Cell Death 1 ReceptorT-LymphocytesAdultAgedAntineoplastic AgentsFemaleHumansHydroxamic AcidsIndolesMaleMiddle AgedPanobinostatAntineoplastic AgentsCytokinesHydroxamic AcidsIndolesNeoplasm ProteinsPanobinostatPDCD1 protein, humanProgrammed Cell Death 1 Receptor

Identifiers

PMID25105535
PMCPMC4219471
OpenAlexW1993916129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.