ArticleVirology2014
Phylogeography and epidemic history of hepatitis C virus genotype 4 in Africa.
Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The epidemiology of hepatitis C virus in the Maghreb region: systematic review and meta-analyses.PloS one · 2015Pooled it
- Characterizing the informativeness of pathogen genome sequence datasets about transmission between population groups.Proceedings. Biological sciences · 2026Article
- Evolving landscape of hepatitis C research in the Eastern Mediterranean Region: A comprehensive bibliometric analysis from 2004 to 2024.Journal of health, population, and nutrition · 2025Article
- Review
- Hepatitis C treatment program in Maputo, Mozambique, the challenge of genotypes and key populations: A 5-year retrospective analysis of routine programmatic data.Health science reports · 2023Article
- Real-World Outcomes of Direct-Acting Antiviral Treatment and Retreatment in United Kingdom-Based Patients Infected With Hepatitis C Virus Genotypes/Subtypes Endemic in Africa.The Journal of infectious diseases · 2022Article
- The evolutionary dynamics and epidemiological history of hepatitis C virus genotype 6, including unique strains from the Li community of Hainan Island, China.Virus evolution · 2022Article
- A mechanistic evolutionary model explains the time-dependent pattern of substitution rates in viruses.Current biology : CB · 2021Article
- Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens.Journal of hepatology · 2021Review
- Review
- Longer Poly(U) Stretches in the 3'UTR Are Essential for Replication of the Hepatitis C Virus Genotype 4a Clone inFrontiers in microbiology · 2021Article
- Epidemic history and baseline resistance to NS5A-specific direct acting drugs of hepatitis C virus in Spain.Scientific reports · 2020Article
- Hepatitis C Virus Infection in Populations With Liver-Related Diseases in the Middle East and North Africa.Hepatology communications · 2020Article
- Key associations for hepatitis C virus genotypes in the Middle East and North Africa.Journal of medical virology · 2020Article
- Suboptimal SVR rates in African patients with atypical genotype 1 subtypes: Implications for global elimination of hepatitis C.Journal of hepatology · 2019Article
- Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study.BMC infectious diseases · 2019Article
- Highly Diverse Hepatitis C Strains Detected in Sub-Saharan Africa Have Unknown Susceptibility to Direct-Acting Antiviral Treatments.Hepatology (Baltimore, Md.) · 2019Article
- Exact limits of inference in coalescent models.Theoretical population biology · 2019Article
- Epidemic history of hepatitis C virus genotypes and subtypes in Portugal.Scientific reports · 2018Article
- An Efficient, Large-Scale Survey of Hepatitis C Viremia in the Democratic Republic of the Congo Using Dried Blood Spots.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
HCV genotype 4 is prevalent in many African countries, yet little is known about the genotype׳s epidemic history on the continent. We present a comprehensive study of the molecular epidemiology of genotype 4. To address the deficit of data from the Democratic Republic of the Congo (DRC) we PCR amplified 60 new HCV isolates from the DRC, resulting in 33 core- and 48 NS5B-region sequences. Our data, together with genotype 4 database sequences, were analysed using Bayesian phylogenetic approaches. We find three well-supported intra-genotypic lineages and estimate that the genotype 4 common ancestor existed around 1733 (1650-1805). We show that genotype 4 originated in central Africa and that multiple lineages have been exported to north Africa since ~1850, including subtype 4a which dominates the epidemic in Egypt. We speculate on the causes of the historical intra-continental spread of genotype 4, including population movements during World War 2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.