ArticleJournal of the American Chemical Society2014
Gangliosides are ligands for human noroviruses.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Stage-Specific Tulane Virus Replication in Zebrafish: Permissive in Embryos, Restricted in Larvae.Food and environmental virology · 2026Article
- Multi-Ligand Interactions Shape Human Norovirus Persistence, Transmission, and Control in Food Matrices.Viruses · 2026Review
- Discovery of Proteinaceous Attachment Factors for GII.4 Norovirus from the Diarrheal Sample of a Norovirus-Infected Patient.Food and environmental virology · 2025Article
- Norovirus-associated neurological manifestations: summarizing the evidence.Journal of neurovirology · 2023Review
- Non-viral gene coating modified IOL delivering PDGFR-α shRNA interferes with the fibrogenic process to prevent posterior capsular opacification.Regenerative biomaterials · 2023Article
- Norovirus-glycan interactions - how strong are they really?Biochemical Society transactions · 2022Article
- The impact of the glycan headgroup on the nanoscopic segregation of gangliosides.Biophysical journal · 2021Article
- Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context.Analytical and bioanalytical chemistry · 2021Review
- Unique Tropism and Entry Mechanism of Mumps Virus.Viruses · 2021Review
- Protein Secondary Structure Affects Glycan Clustering in Native Mass Spectrometry.Life (Basel, Switzerland) · 2021Article
- NMR Experiments Shed New Light on Glycan Recognition by Human and Murine Norovirus Capsid Proteins.Viruses · 2021Article
- Human Norovirus Replication in Temperature-Optimized MDCK Cells by Forkhead Box O1 Inhibition.Journal of microbiology and biotechnology · 2020Article
- Characterization of human norovirus binding to gut-associated bacterial ligands.BMC research notes · 2019Article
- GII.13/21 Noroviruses Recognize Glycans with a Terminal β-Galactose via an Unconventional Glycan Binding Site.Journal of virology · 2019Article
- Animals as Reservoir for Human Norovirus.Viruses · 2019Review
- Structural basis of host ligand specificity change of GII porcine noroviruses from their closely related GII human noroviruses.Emerging microbes & infections · 2019Article
- Quantifying the binding stoichiometry and affinity of histo-blood group antigen oligosaccharides for human noroviruses.Glycobiology · 2018Article
- Article
- Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens.Journal of virology · 2018Article
- Norovirus Binding to Ligands Beyond Histo-Blood Group Antigens.Frontiers in microbiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human noroviruses (NoVs) are known to recognize histo-blood group antigens (HBGAs) as attachment factors. We report the first experimental evidence that sialic acid-containing glycosphingolipids (gangliosides) are also ligands for human NoVs. Electrospray ionization mass spectrometry-based carbohydrate binding measurements performed on assemblies (P dimer, P particle, and virus-like particle) of recombinant viral capsid proteins of two NoV strains, VA387 (GII.4) and VA115 (GI.3), identified binding to the oligosaccharides of mono-, di-, and trisialylated gangliosides. The intrinsic (per binding site) affinities measured for these ligands are similar in magnitude (10(2)-10(3) M(-1)) to those of human HBGAs. Binding of NoV VLPs, P particles, and glutathione S-transferase (GST)-P domain fusion proteins to sialic acid-containing glycoconjugates, observed in enzyme-linked immunosorbent assays, provided additional confirmation of the NoV-ganglioside interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.