Evidence map›Paper›PMID 25105417›Full record

ArticlePloS one2014

Beneficial effect of isoniazid preventive therapy and antiretroviral therapy on the incidence of tuberculosis in people living with HIV in Ethiopia.

Kesetebirhan Delele Yirdaw, Degu Jerene, Zewdu Gashu, M E Edginton, Ajay M V Kumar, Yohannes Letamo, Beniam Feleke, Alula M Teklu, Solomon Zewdu, Bill Weiss and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537872 (PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study), which is not on this map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03537872 nacompletednot on this mapstarted 2018, after this paper: background citation

PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study (PROMISE Study)

TypeinterventionalSponsorColumbia UniversityRan2018 to 2019Enrolled248ConditionsHIVArmsMiner-Friendly (MF) Service Venues TB/HIV Integration Strategies, Public Sector (PS) Health Facilities TB/HIV Integration Strategies
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Kesetebirhan Delele YirdawClinical Department, Johns Hopkins University TSEHAI Project, Addis Ababa, Ethiopia.
Degu JereneClinical Department, Johns Hopkins University TSEHAI Project, Addis Ababa, Ethiopia.
Zewdu GashuClinical Department, Johns Hopkins University TSEHAI Project, Addis Ababa, Ethiopia.
M E EdgintonCenter for Operational Research, International Union against Tuberculosis and Lung Disease, Paris, France.
Ajay M V KumarInternational Union against Tuberculosis and Lung Disease, South-East Asia Regional Office, New Delhi, India.
Yohannes LetamoHealth Research and Technology Transfer Support Process, Southern Nations Nationalities and People's Region Health Bureau, Hawassa, Southern Nations Nationalities and People's Region, Ethiopia.
Beniam FelekeCare and treatment branch, TB/HIV unit, Centers for Disease Control and Prevention, Addis Ababa, Ethiopia.
Alula M TekluPCM Department, Johns Hopkins University TSEHAI Project, Addis Ababa, Ethiopia.
Solomon ZewduBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Bill WeissBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Andrea RuffBloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.
Johns Hopkins University · USAddis Ababa University · ETAfrica Centres for Disease Control and Prevention · ETInternational Union Against Tuberculosis and Lung Disease · FRInternational Union Against Tuberculosis and Lung Disease · USSouthern Nations, Nationalities, and Peoples' Region · ET

Funding

TECHNICAL SUPPORT IN HIV TREATMENT, CARE AND PREVENTION IN ETHIOPIAU2GPS000858 · PS · JOHNS HOPKINS UNIVERSITY · PI RUFF, ANDREA JENAY · 2007 to 2013
$76.5M
NCHHSTP CDC HHS U2G PS000858PEPFAR U2GPS000858
6 · The paper itself

Abstract

backgroundIPT with or without concomitant administration of ART is a proven intervention to prevent tuberculosis among PLHIV. However, there are few data on the routine implementation of this intervention and its effectiveness in settings with limited resources.

objectivesTo measure the level of uptake and effectiveness of IPT in reducing tuberculosis incidence in a cohort of PLHIV enrolled into HIV care between 2007 and 2010 in five hospitals in southern Ethiopia.

methodsA retrospective cohort analysis of electronic patient database was done. The independent effects of no intervention, "IPT-only," "IPT-before-ART," "IPT-and-ART started simultaneously," "ART-only," and "IPT-after-ART" on TB incidence were measured. Cox-proportional hazards regression was used to assess association of treatment categories with TB incidence.

resultsOf 7,097 patients, 867 were excluded because they were transferred-in; a further 823 (12%) were excluded from the study because they were either identified to have TB through screening (292 patients) or were on TB treatment (531). Among the remaining 5,407 patients observed, IPT had been initiated for 39% of eligible patients. Children, male sex, advanced disease, and those in Pre-ART were less likely to be initiated on IPT. The overall TB incidence was 2.6 per 100 person-years. As compared to those with no intervention, use of "IPT-only" (aHR = 0.36, 95% CI = 0.19-0.66) and "ART-only" (aHR = 0.32, 95% CI = 0.24-0.43) were associated with significant reduction in TB incidence rate. Combining ART and IPT had a more profound effect. Starting IPT-before-ART (aHR = 0.18, 95% CI = 0.08-0.42) or simultaneously with ART (aHR = 0.20, 95% CI = 0.10-0.42) provided further reduction of TB at ∼ 80%.

conclusionsIPT was found to be effective in reducing TB incidence, independently and with concomitant ART, under programme conditions in resource-limited settings. The level of IPT provision and effectiveness in reducing TB was encouraging in the study setting. Scaling up and strengthening IPT service in addition to ART can have beneficial effect in reducing TB burden among PLHIV in settings with high TB/HIV burden.

Indexed as

AdolescentAdultAgedAged, 80 and overAnti-Retroviral AgentsAntitubercular AgentsChildChild, PreschoolCohort StudiesEthiopiaFemaleHIV InfectionsHumansIncidenceInfantIsoniazidAnti-Retroviral AgentsAntitubercular AgentsIsoniazid

Identifiers

PMID25105417
PMCPMC4126726
OpenAlexW1979160389

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.