ArticleScientific reports2014
Protein localization analysis of essential genes in prokaryotes.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Acetylome Analysis inPathogens (Basel, Switzerland) · 2026Article
- Aggregation in gut: on the link between neurodegeneration and bacterial functional amyloids.NPJ biofilms and microbiomes · 2026Article
- Recent advances in the characterization of essential genes and development of a database of essential genes.iMeta · 2024Review
- Genome-wide identification of the opsin protein inFrontiers in microbiology · 2023Article
- Kin selection for cooperation in natural bacterial populations.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Bacterial genome reductions: Tools, applications, and challenges.Frontiers in genome editing · 2022Review
- Genome-wide characterization of laccase gene family inFrontiers in microbiology · 2022Article
- Elucidating Essential Genes in Plant-Associated Pseudomonas protegens Pf-5 Using Transposon Insertion Sequencing.Journal of bacteriology · 2021Article
- Bacterial Protein Interaction Networks: Connectivity is Ruled by Gene Conservation, Essentiality and Function.Current genomics · 2021Article
- Article
- New insights on human essential genes based on integrated analysis and the construction of the HEGIAP web-based platform.Briefings in bioinformatics · 2020Article
- A systematic strategy for the investigation of vaccines and drugs targeting bacteria.Computational and structural biotechnology journal · 2020Review
- Genome-Wide Identification and Analysis of Chitinase GH18 Gene Family inFrontiers in microbiology · 2020Article
- Quantifying Gene Essentiality Based on the Context of Cellular Components.Frontiers in genetics · 2019Article
- Identification of novel drug targets in bovine respiratory disease: an essential step in applying biotechnologic techniques to develop more effective therapeutic treatments.Drug design, development and therapy · 2018Article
- A Comprehensive Overview of Online Resources to Identify and Predict Bacterial Essential Genes.Frontiers in microbiology · 2017Review
- Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes.Scientific reports · 2015Article
- Comparative analysis of essential genes in prokaryotic genomic islands.Scientific reports · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential genes, those critical for the survival of an organism under certain conditions, play a significant role in pharmaceutics and synthetic biology. Knowledge of protein localization is invaluable for understanding their function as well as the interaction of different proteins. However, systematical examination of essential genes from the aspect of the localizations of proteins they encode has not been explored before. Here, a comprehensive protein localization analysis of essential genes in 27 prokaryotes including 24 bacteria, 2 mycoplasmas and 1 archaeon has been performed. Both statistical analysis of localization information in these genomes and GO (Gene Ontology) terms enriched in the essential genes show that proteins encoded by essential genes are enriched in internal location sites, while exist in cell envelope with a lower proportion compared with non-essential ones. Meanwhile, there are few essential proteins in the external subcellular location sites such as flagellum and fimbrium, and proteins encoded by non-essential genes tend to have diverse localizations. These results would provide further insights into the understanding of fundamental functions needed to support a cellular life and improve gene essentiality prediction by taking the protein localization and enriched GO terms into consideration.
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