ArticlePloS one2014
Genomic characterization of a large outbreak of Legionella pneumophila serogroup 1 strains in Quebec City, 2012.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
- Comparative genome analysis investigation of nosocomial and community-acquired cases of Legionnaires' disease caused by ST2858 and ST378.Microbiology spectrum · 2025Article
- Rapid adaptations ofMicrobial genomics · 2023Article
- Polymer Brushes on GaAs and GaAs/AlGaAs Nanoheterostructures: A Promising Platform for Attractive Detection ofACS omega · 2022Article
- Culture-Free Phylogenetic Analysis of Legionella pneumophila Using Targeted CRISPR/Cas9 Next-Generation Sequencing.Microbiology spectrum · 2022Article
- Investigation of Conditions for Capture of LiveBiosensors · 2022Article
- A Tale of Four Danish Cities:International journal of environmental research and public health · 2022Article
- Bacterial Antagonistic Species of the Pathogenic GenusMicroorganisms · 2022Article
- Local Adaptation of Legionella pneumophila within a Hospital Hot Water System Increases Tolerance to Copper.Applied and environmental microbiology · 2021Article
- Effects of climate changes and road exposure on the rapidly rising legionellosis incidence rates in the United States.PloS one · 2021Article
- Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2020Article
- Pathogen Genomics in Public Health.The New England journal of medicine · 2019Article
- Comparison of Database Search Methods for the Detection ofFrontiers in microbiology · 2018Article
- Epidemiological information is key when interpreting whole genome sequence data - lessons learned from a largeEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Article
- Legionnaires' Disease Outbreaks and Cooling Towers, New York City, New York, USA.Emerging infectious diseases · 2017Article
- Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires' Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Unusual Legionnaires' outbreak in cool, dry Western Canada: an investigation using genomic epidemiology.Epidemiology and infection · 2017Article
- Energy Conservation and the Promotion of Legionella pneumophila Growth: The Probable Role of Heat Exchangers in a Nosocomial Outbreak.Infection control and hospital epidemiology · 2016Article
- Multiplication of Legionella pneumophila Sequence Types 1, 47, and 62 in Buffered Yeast Extract Broth and Biofilms Exposed to Flowing Tap Water at Temperatures of 38°C to 42°C.Applied and environmental microbiology · 2016Article
- Evaluation of an Optimal Epidemiological Typing Scheme for Legionella pneumophila with Whole-Genome Sequence Data Using Validation Guidelines.Journal of clinical microbiology · 2016Article
- Two Related Occupational Cases of Legionella longbeachae Infection, Quebec, Canada.Emerging infectious diseases · 2016Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the summer of 2012, a major Legionella pneumophila serogroup 1 outbreak occurred in Quebec City, Canada, which caused 182 declared cases of Legionnaire's disease and included 13 fatalities. Legionella pneumophila serogroup 1 isolates from 23 patients as well as from 32 cooling towers located in the vicinity of the outbreak were recovered for analysis. In addition, 6 isolates from the 1996 Quebec City outbreak and 4 isolates from patients unrelated to both outbreaks were added to allow comparison. We characterized the isolates using pulsed-field gel electrophoresis, sequence-based typing, and whole genome sequencing. The comparison of patients-isolated strains to cooling tower isolates allowed the identification of the tower that was the source of the outbreak. Legionella pneumophila strain Quebec 2012 was identified as a ST-62 by sequence-based typing methodology. Two new Legionellaceae plasmids were found only in the epidemic strain. The LVH type IV secretion system was found in the 2012 outbreak isolates but not in the ones from the 1996 outbreak and only in half of the contemporary human isolates. The epidemic strains replicated more efficiently and were more cytotoxic to human macrophages than the environmental strains tested. At least four Icm/Dot effectors in the epidemic strains were absent in the environmental strains suggesting that some effectors could impact the intracellular replication in human macrophages. Sequence-based typing and pulsed-field gel electrophoresis combined with whole genome sequencing allowed the identification and the analysis of the causative strain including its likely environmental source.
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