SynthesisNature communications2014
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 10 pooled it
8.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 10 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.Nature genetics · 2023Pooled it
- Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians.International journal of cancer · 2022Pooled it
- Discovery of common and rare genetic risk variants for colorectal cancer.Nature genetics · 2019Pooled it
- Telomere structure and maintenance gene variants and risk of five cancer types.International journal of cancer · 2016Pooled it
- Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.Journal of the National Cancer Institute · 2015Pooled it
- Genome-wide association study identifies multiple susceptibility loci for glioma.Nature communications · 2015Pooled it
- Genome-wide association study of colorectal cancer identifies six new susceptibility loci.Nature communications · 2015Pooled it
- Common genetic variants (rs4779584 and rs10318) at 15q13.3 contributes to colorectal adenoma and colorectal cancer susceptibility: evidence based on 22 studies.Molecular genetics and genomics : MGG · 2015Pooled it
- A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.Scientific reports · 2015Pooled it
- Interaction between Red Meat Intake and NAT2 Genotype in Increasing the Risk of Colorectal Cancer in Japanese and African Americans.PloS one · 2015Pooled it
- A Swedish Haplotype GWAS in Familial and Sporadic Site-Specific Colorectal Cancer.International journal of molecular sciences · 2026Article
- Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk.British journal of cancer · 2024Article
- Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations.Nature communications · 2023Article
- Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study.Journal of the National Cancer Institute · 2022Article
- Repurposing non-invasive prenatal testing data: Population study of single nucleotide variants associated with colorectal cancer and Lynch syndrome.Oncology letters · 2021Article
- Association of four genetic variants with colorectal cancer in Kazakhstan population.Oncotarget · 2021Article
- Non-Lynch Familial and Early-Onset Colorectal Cancer Explained by Accumulation of Low-Risk Genetic Variants.Cancers · 2021Article
- Multi-omics analysis to identify susceptibility genes for colorectal cancer.Human molecular genetics · 2021Article
- Identifying Novel Susceptibility Genes for Colorectal Cancer Risk From a Transcriptome-Wide Association Study of 125,478 Subjects.Gastroenterology · 2021Article
- A transcription-centric model of SNP-age interaction.PLoS genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
38 authors at 20 institutions in 9 countries.
Hansong WangEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Terrilea BurnettEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Suminori KonoDepartment of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8581, Japan.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
Motoki IwasakiResearch Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Lenora W M LooEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
David Van Den BergDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Robert S SandlerCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Lisa B Signorello1] Department of Epidemiology, Harvard School of Public Health, and the Channing Division of Network Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Dana-Farber/Harvard Cancer Center, Boston, Massachusetts 02115, USA.
William J Blot1] Division of Epidemiology, Vanderbilt University Medical Center/Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37235, USA [2] International Epidemiology Institute, Rockville, Maryland 20850, USA.
Polly A NewcombCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
Mala PandeDepartment of Gastroenterolgy-Research, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Christopher I AmosDepartment of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire 03755, USA.
Dee W WestCancer Prevention Institute of California, Fremont, California 94538, USA.
Stéphane BézieauService de Génétique Médicale, CHU Nantes, 44093 Nantes, France.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Brent W ZankeDivision of Hematology, Faculty of Medicine, University of Ottawa and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1J8M5.
Li HsuCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)
Noralane M LindorEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Robert W HaileEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
John L HopperEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Mark A JenkinsEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Steven GallingerCancer Care Ontario, Toronto, Ontario, Canada M5G 2L3.
Graham CaseyDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
Colon Cancer Family Registry (CCFR)
Stephanie L StenzelDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
Fredrick R SchumacherEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Ulrike PetersCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington 19024, USA.
Stephen B GruberEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Colorectal Transdisciplinary Study (CORECT)
Shoichiro TsuganeResearch Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA.
Loïc Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Fred Hutch Cancer Center · USUniversity of Southern California · USUniversity of Hawaiʻi at Mānoa · USUniversity of Hawaii Cancer CenterNational Institutes of Health · USBrigham and Women's Hospital · USCancer Care Ontario · CACancer Center of Hawaii · USUniversity of Hawaii System · USUniversity of North Carolina at Chapel Hill · USGénétique Médicale & Génomique Fonctionelle · FRHeidelberg University · DENational Cancer Institute · USUniversity of Michigan–Ann Arbor · USAmerican Cancer Society · USHarvard University · USMayo Clinic in Arizona · USTranslational Genomics Research Institute · USUniversity of Melbourne · AUCancer Prevention Institute of California · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MSouthern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2MPILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MCIHRIntramural NIH HHS Z01 CP010200NCI NIH HHS 1R01-CA104132NCI NIH HHS 1R01-CA126895NCI NIH HHS 1R01-CA126895-S1NCI NIH HHS 2U24-CA074806NCI NIH HHS CA 087969NCI NIH HHS CA16672NCI NIH HHS CA-95-011NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA160753NCI NIH HHS K07CA160753NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA 055075NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA 087969NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA 106991NCI NIH HHS P50 CA106991NCI NIH HHS P50 CA 127003NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA066635NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA092447NCI NIH HHS R01CA092447NCI NIH HHS R01 CA104132NCI NIH HHS R01 CA126895NCI NIH HHS R01-CA1326792NCI NIH HHS R01 CA132839NCI NIH HHS R01-CA132839NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA48998NCI NIH HHS R01 CA60987NCI NIH HHS R01 CA63464NCI NIH HHS R01 CA 66635NCI NIH HHS R01 CA81488NCI NIH HHS R37 CA054281NCI NIH HHS R37 CA54281NCI NIH HHS RC2 CA148085NCI NIH HHS RC2-CA148085NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA 093326NCI NIH HHS U01 CA093326NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG 004438NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004726NHGRI NIH HHS U01-HG004726NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK058404NIEHS NIH HHS T32 ES013678PHS HHS R01 137178
Abstract
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAllelesAsian PeopleBlack or African AmericanCase-Control StudiesChromosome MappingColorectal NeoplasmsGenetic LociGenotypeHumansJapanPolymorphism, Single NucleotideQb-SNARE ProteinsUnited StatesWhite PeopleQb-SNARE ProteinsVTI1A protein, human
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