Evidence map›Paper›PMID 25105018›Full record

ReviewJournal of ophthalmology2014

The ocular surface chemical burns.

Medi Eslani, Alireza Baradaran-Rafii, Asadolah Movahedan, Ali R Djalilian

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04626583 phase1completednot on this mapstarted 2021, after this paper: background citation

Safety of Locally Delivered Allogeneic Mesenchymal Stromal Cells for Promoting Corneal Repair

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2021 to 2023Enrolled8ConditionsMesenchymal Stromal Cells, Cornea, Safety, Corneal DefectArmsAllogeneic MSC
NCT05705024 phase2recruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy of Locally Delivered Allogeneic Mesenchymal Stem Cells for Promoting Corneal Repair

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2023 to 2026Enrolled38ConditionsCorneal UlcerArmsMesenchymal Stromal Cells, Control Solution
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Role of Neutrophils on the Ocular Surface.International journal of molecular sciences · 2021
    Pooled it
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Medi EslaniDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-3647-0250
Alireza Baradaran-RafiiLabbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asadolah MovahedanDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-5759-6579
Ali R DjalilianDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Novel Therapies for Ocular Chemical InjuriesR01EY024349 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DJALILIAN, ALI R · 2015 to 2020
$2.1M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY024349
6 · The paper itself

Abstract

Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease. The goal of treatment is to restore the normal ocular surface anatomy and function. Limbal stem cell transplantation, amniotic membrane transplantation, and ultimately keratoprosthesis may be indicated depending on the patients' needs.

Identifiers

PMID25105018
PMCPMC4106115

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.