ArticleHeart views : the official journal of the Gulf Heart Association2014
The Efficacy of Hydration with Normal Saline Versus Hydration with Sodium Bicarbonate in the Prevention of Contrast-induced Nephropathy.
Article in Heart views : the official journal of the Gulf Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Hydration Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-Analysis.Journal of interventional cardiology · 2020Pooled it
- Sodium bicarbonate versus isotonic saline solution to prevent contrast-induced nephropathy : a systematic review and meta-analysis.Colombia medica (Cali, Colombia) · 2015Pooled it
- Pooled it
- Trimetazidine effect on kidney function in patients undergoing coronary procedures.BMC pharmacology & toxicology · 2025Observational
- The Prevention and Management of Contrast-induced Acute Kidney Injury: A Mini-review of the Literature.Cureus · 2018Review
- Tumor-Like Liver Abscess Mimicking Malignancy With Lung Metastases in a Patient With Acute Renal Failure: A Case Report.Medicine · 2016Article
- Standards of anesthesiology practice during neuroradiological interventions.Open medicine (Warsaw, Poland) · 2016Article
- Treatment and management of ascites and hepatorenal syndrome: an update.Therapeutic advances in gastroenterology · 2015Review
- Article
- Current status of sodium bicarbonate in coronary angiography: an updated comprehensive meta-analysis and systematic review.Cardiology research and practice · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContrast-induced acute kidney injury [contrast-induced nephropathy (CIN)] is one of the major causes of hospital-acquired acute renal failure. Volume supplementation is the most effective strategy to prevent acute renal failure caused by contrast; but the effects of sodium bicarbonate regimens are unknown in CIN prevention. The aim of this survey is to compare the efficacy of hydration with normal saline versus hydration with sodium bicarbonate in the prevention of the CIN in patients undergoing coronary angiography. MATERIALS AND
methodsIn a clinical trial, 350 patients undergoing coronary interventions were randomized into two groups: One group received normal saline and another group received sodium bicarbonate before and after infusion of the contrast. Patients in both the groups had received N-acetylcysteine. CIN was defined as relative increase in serum creatinine equal to or more than 25% of baseline or increase to 0.5 mg/dl in 48 h after the injection of the contrast.
resultsCIN was seen in 46 patients (13.1%) after coronary interventions. Incidence of CIN in patients receiving normal saline (19.4%) was more than in patients receiving sodium bicarbonate (6.9%) (P = 0.001). Hemodialysis was needed only in one patient who received saline normal. Relative risk to induce CIN in both groups was as 2.8 and was in the range of 1.50-5.25 with confidence interval of 95% and P = 0.001. Thus, the probability of CIN was significantly more in the usage of normal saline.
conclusionThis survey showed that hydration with sodium bicarbonate is superior to hydration with normal saline and has better protection effects.
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