ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
129 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multimorbidity and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Pooled it
- Collaborative Care for Psychiatric Disorders in Older Adults: A Systematic Review.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Multimorbidity in Patients With Acute Coronary Syndrome Is Associated With Greater Mortality, Higher Readmission Rates, and Increased Length of Stay: A Systematic Review.The Journal of cardiovascular nursingPooled it
- Calprotectin identified as a key differentially expressed plasma biomarker in periprosthetic joint infection against aseptic failure: a precision health proteomics study.Arthroplasty (London, England) · 2026Article
- A Defined Synbiotic Produces Immunomodulatory Metabolites, Engages Gut-Immune Pathways Relevant to Inflammaging, and Supports Healthy Aging in a Nematode Model.International journal of molecular sciences · 2026Article
- Longitudinal analysis of cytokines, chemokines, and inflammatory markers in a middle-aged cohort.GeroScience · 2026Article
- Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study.BMC medicine · 2026Article
- Shared and specific blood biomarkers for multimorbidity.Nature medicine · 2026Article
- Prognostic Value of Handgrip Strength in Older Patients With Heart Failure: A Post Hoc Analysis of FRAGILE-HF.Journal of the American Heart Association · 2026Article
- Functional dependency level and later-life incident multimorbidity in older people: longitudinal evidence from 19 countries in China and Europe.BMC public health · 2025Article
- Prognostic value of three inflammatory markers for mortality after hip fracture in the geriatric population.Scientific reports · 2025Article
- How are chronic diseases related to depressive symptoms in older adults? The role of life satisfaction and multidimensional intergenerational relationships.BMC geriatrics · 2025Article
- The relationship between frailty and multimorbidity in Chinese older adults: the chain mediating effects of sleep quality and anxiety.BMC geriatrics · 2025Article
- The role of cellular senescence in cardiovascular disease.Cell death discovery · 2025Review
- Association Between Ultra-Processed Food Consumption Frequency and Frailty: Findings from the InCHIANTI Study of Aging.Geriatrics (Basel, Switzerland) · 2025Article
- Dietary patterns and accelerated multimorbidity in older adults.Nature aging · 2025Article
- Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Increasing Educational Inequality in Biological Aging Among U.S. Adults Aged 50-79 From 1988-1994 to 2015-2018.Demography · 2025Article
- Multimorbidity, Muscle Strength, and Falls among Older Mexican Americans.Journal of the American Medical Directors Association · 2025Article
69 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
backgroundMultimorbidity increases with aging, but risk factors beyond age are unknown.
objectiveTo investigate the association of inflammatory and anabolic hormonal biomarkers with presence and prospective development of multimorbidity.
methodsNine-year longitudinal study of 1018 participants aged 60 years or older (InCHIANTI Study). Multimorbidity was evaluated at baseline and follow-up visits as number of diagnosed diseases from a predefined list of 15 candidate chronic conditions, defined according to standard clinical criteria. Linear mixed models were used to test cross-sectional and longitudinal associations between candidate biomarkers and multimorbidity.
resultsAt baseline, multimorbidity was significantly higher in older participants (p < .001) and higher IL-6, IL-1ra, TNF-α receptor II (TNFAR2), and lower dehydroepiandrosterone sulfate were associated with higher number of diseases, independent of age, sex, body mass index, and education. The rate of longitudinal increase in number of chronic diseases was significantly steeper in participants who were older at baseline (p < .001). In addition, higher baseline IL-6 and steeper increase of IL-6 levels were significantly and independently associated with a steeper increase in multimorbidity over time (p < .001 and p = .003, respectively). Sensitivity analyses, performed using 15 different models obtained by removing each of 15 conditions included in the original list of candidate diseases, confirmed that results were not driven by any specific condition.
conclusionsAccumulation of chronic diseases accelerates at older ages and in persons with higher baseline levels and steeper increase over time of IL-6. High IL-6 and increase in IL-6 may serve as early warning sign to better target interventions aimed at reducing the burden of multimorbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.