ArticlePlant physiology2014
TRANSLOCASE OF THE INNER MEMBRANE9 and 10 are essential for maintaining mitochondrial function during early embryo cell and endosperm free nucleus divisions in Arabidopsis.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 48 citations in OpenAlex.
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- Arabidopsis TIC236 contributes to proplastid development and chloroplast biogenesis during embryogenesis.Frontiers in plant science · 2024Article
- Rice DSP controls stigma, panicle and tiller primordium initiation.Plant biotechnology journal · 2023Article
- Metabolic evidence for distinct pyruvate pools inside plant mitochondria.Nature plants · 2022Article
- Cellular oxidative stress in programmed cell death: focusing on chloroplasticJournal of plant research · 2021Article
- OsMre11 Is Required for Mitosis during Rice Growth and Development.International journal of molecular sciences · 2020Article
- Mitochondrial dynamics and segregation during the asymmetric division ofQuantitative plant biology · 2020Article
- Expression and Distribution of the Auxin Response Factors inInternational journal of molecular sciences · 2019Article
- MaizePlant physiology · 2019Article
- Translocase of the Outer Mitochondrial Membrane 40 Is Required for Mitochondrial Biogenesis and Embryo Development inFrontiers in plant science · 2019Article
- PtWOX11 acts as master regulator conducting the expression of key transcription factors to induce de novo shoot organogenesis in poplar.Plant molecular biology · 2018Article
- Pollen-Expressed Leucine-Rich Repeat Extensins Are Essential for Pollen Germination and Growth.Plant physiology · 2018Article
- CELLULASE6 and MANNANASE7 Affect Cell Differentiation and Silique Dehiscence.Plant physiology · 2018Article
- Subunit Interaction Differences Between the Replication Factor C Complexes inFrontiers in plant science · 2018Article
- Article
- A role for small RNA in regulating innate immunity during plant growth.PLoS pathogens · 2018Article
- Seed weight differences between wild and domesticated soybeans are associated with specific changes in gene expression.Plant cell reports · 2017Article
- Functional divergence of chloroplast Cpn60α subunits during Arabidopsis embryo development.PLoS genetics · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the life cycle of flowering plants, the sporophytic generation takes up most of the time and plays a dominant role in influencing plant growth and development. The embryo cell and endosperm free nucleus divisions establish the critical initiation phase of early sporophyte development, which forms mature seeds through a series of cell growth and differentiation events. Here, we report on the biological functions of two Arabidopsis (Arabidopsis thaliana) mitochondrial proteins, TRANSLOCASE OF THE INNER MEMBRANE9 (TIM9) and TIM10. We found that dysfunction of either AtTIM9 or AtTIM10 led to an early sporophyte-lethal phenotype; the embryo and endosperm both arrest division when the embryo proper developed to 16 to 32 cells. The abortion of tim9-1 and tim10 embryos at the 16/32-cell stage was caused by the loss of cell viability and the cessation of division in the embryo proper region, and this inactivation was due to the collapse of the mitochondrial structure and activity. Our characterization of tim9-1 and tim10 showed that mitochondrial membrane permeability increased and that cytochrome c was released from mitochondria into the cytoplasm in the 16/32-cell embryo proper, indicating that mitochondrial dysfunction occurred in the early sporophytic cells, and thus caused the initiation of a necrosis-like programmed cell death, which was further proved by the evidence of reactive oxygen species and DNA fragmentation tests. Consequently, we verified that AtTIM9 and AtTIM10 are nonredundantly essential for maintaining the mitochondrial function of early embryo proper cells and endosperm-free nuclei; these proteins play critically important roles during sporophyte initiation and development in Arabidopsis.
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