ArticleGenes & development2014
The exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript.
Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 63 citations in OpenAlex.
- Chemical inhibition of exon junction complex assembly impairs mRNA localization and neural stem cells ciliogenesis.Nucleic acids research · 2025Article
- Comprehensive mapping of exon junction complex binding sites reveals universal EJC deposition in Drosophila.BMC biology · 2023Article
- The NSL complex is required for piRNA production from telomeric clusters.Life science alliance · 2023Article
- A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration.Protein & cell · 2023Article
- Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance.Nucleic acids research · 2022Article
- Role of main RNA modifications in cancer: NSignal transduction and targeted therapy · 2022Review
- Review
- A phosphoswitch at acinus-serineeLife · 2022Article
- An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.EMBO reports · 2022Article
- Molecular and genetic dissection of recursive splicing.Life science alliance · 2022Article
- The Exon Junction Complex and intron removal prevent re-splicing of mRNA.PLoS genetics · 2021Article
- Chemical crosslinking enhances RNA immunoprecipitation for efficient identification of binding sites of proteins that photo-crosslink poorly with RNA.RNA (New York, N.Y.) · 2020Article
- A Day in the Life of the Exon Junction Complex.Biomolecules · 2020Review
- Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.Developmental cell · 2020Article
- Dosage-dependent requirements ofDevelopment (Cambridge, England) · 2020Article
- The piRNA pathway in Drosophila ovarian germ and somatic cells.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Review
- The exon junction complex is required for stem and progenitor cell maintenance in planarians.Developmental biology · 2020Article
- Promoter-proximal pausing mediated by the exon junction complex regulates splicing.Nature communications · 2019Article
- The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity.Cell reports · 2018Article
- Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events.Scientific reports · 2018Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The exon junction complex (EJC) is a highly conserved ribonucleoprotein complex that binds RNAs during splicing and remains associated with them following export to the cytoplasm. While the role of this complex in mRNA localization, translation, and degradation has been well characterized, its mechanism of action in splicing a subset of Drosophila and human transcripts remains to be elucidated. Here, we describe a novel function for the EJC and its splicing subunit, RnpS1, in preventing transposon accumulation in both Drosophila germline and surrounding somatic follicle cells. This function is mediated specifically through the control of piwi transcript splicing, where, in the absence of RnpS1, the fourth intron of piwi is retained. This intron contains a weak polypyrimidine tract that is sufficient to confer dependence on RnpS1. Finally, we demonstrate that RnpS1-dependent removal of this intron requires splicing of the flanking introns, suggesting a model in which the EJC facilitates the splicing of weak introns following its initial deposition at adjacent exon junctions. These data demonstrate a novel role for the EJC in regulating piwi intron excision and provide a mechanism for its function during splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.