Evidence map›Paper›PMID 25104262›Full record

Trial reportThe Lancet. Global health2013

Abbreviated HIV counselling and testing and enhanced referral to care in Uganda: a factorial randomised controlled trial.

Rhoda K Wanyenze, Moses R Kamya, Robin Fatch, Harriet Mayanja-Kizza, Steven Baveewo, Gregory Szekeres, David R Bangsberg, Thomas Coates, Judith A Hahn

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Lancet. Global health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00648232 (HIV Counseling and Testing and Linkage to Care in Uganda), which is not on this map. Cited by 25 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 7 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00648232 nacompletednot on this map

HIV Counseling and Testing and Linkage to Care in Uganda

TypeinterventionalSponsorUniversity of California, Los AngelesRan2008 to 2011Enrolled3,415ConditionsHIV InfectionsArmsVoluntary brief HIV counseling and testing, Voluntary longer, more detailed HIV counseling and testing, Enhanced linkage to care, Routine referral to care
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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  8. Reducing HIV-Associated Post-Hospital Mortality Through Home-Based Care in South Africa: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
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  11. HIV infection.Nature reviews. Disease primers · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Rhoda K WanyenzeDepartment of Disease Control and Environmental Health, Makerere University School of Public Health, Kampala, Uganda. Electronic address: rwanyenze@hotmail.com.
Moses R KamyaDepartment of Medicine, Makerere University School of Medicine, Kampala, Uganda.
Robin FatchDepartment of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Harriet Mayanja-KizzaDepartment of Medicine, Makerere University School of Medicine, Kampala, Uganda.
Steven BaveewoDepartment of Medicine, Makerere University School of Medicine, Kampala, Uganda.
Gregory SzekeresDivision of Infectious Diseases, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
David R BangsbergMassachusetts General Hospital Center for Global Health and Harvard Medical School, Boston, MA, USA.
Thomas CoatesDivision of Infectious Diseases, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.
Judith A HahnDepartment of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA.
Makerere University · UGUniversity of California, Los Angeles · USMassachusetts General Hospital · USSan Francisco General Hospital · USUniversity of California, San Francisco · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMIESON-KARAVODIN, BETH DEIRDRE · 1991 to 2018
$39.9M
HIV VCT and Linkage to Care in UgandaR01MH077512 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COATES, THOMAS J. · 2007 to 2011
$2.5M
Training in Research Program on Alcohol Use by Persons with our at Risk for HIVK24AA022586 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAHN, JUDITH ALISSA · 2013 to 2023
$1.8M
NCATS NIH HHS UL1 TR000124NIAAA NIH HHS K24 AA022586NIAID NIH HHS P30 AI028697NIMH NIH HHS 1 R01 MH077512NIMH NIH HHS P30 MH058107NIMH NIH HHS R01 MH077512
6 · The paper itself

Abstract

backgroundHIV counselling and testing and linkage to care are crucial for successful HIV prevention and treatment. Abbreviated counselling could save time; however, its effect on HIV risk is uncertain and methods to improve linkage to care have not been studied.

methodsWe did this factorial randomised controlled study at Mulago Hospital, Uganda. Participants were randomly assigned to abbreviated or traditional HIV counselling and testing; HIV-infected patients were randomly assigned to enhanced linkage to care or standard linkage to care. All study personnel except counsellors and the data officer were masked to study group assignment. Participants had structured interviews, given once every 3 months. We compared sexual risk behaviour by counselling strategy with a 6·5% non-inferiority margin. We used Cox proportional hazards analyses to compare HIV outcomes by linkage to care over 1 year and tested for interaction by sex. This trial is registered with ClinicalTrials.gov (NCT00648232).

findingsWe enrolled 3415 participants; 1707 assigned to abbreviated counselling versus 1708 assigned to traditional. Unprotected sex with an HIV discordant or status unknown partner was similar in each group (232/823 [27·9%] vs 251/890 [28·2%], difference -0·3%, one-sided 95% CI 3·2). Loss to follow-up was lower for traditional counselling than for abbreviated counselling (adjusted hazard ratio [HR] 0·61, 95% CI 0·44-0·83). 1003 HIV-positive participants were assigned to enhanced linkage (n=504) or standard linkage to care (n=499). Linkage to care did not have a significant effect on mortality or receipt of co-trimoxazole. Time to treatment in men with CD4 cell counts of 250 cells per μL or fewer was lower for enhanced linkage versus standard linkage (adjusted HR 0·60, 95% CI 0·41-0·87) and time to HIV care was decreased among women (0·80, 0·66-0·96).

interpretationAbbreviated HIV counselling and testing did not adversely affect risk behaviour. Linkage to care interventions might decrease time to enrolment in HIV care and antiretroviral treatment and thus might affect secondary HIV transmission and improve treatment outcomes.

fundingUS National Institute of Mental Health.

Indexed as

Referral and ConsultationRisk-TakingTime-to-TreatmentAdultCD4 Lymphocyte CountCounselingDisease ManagementFemaleHIV InfectionsHumansMaleProportional Hazards ModelsRisk AssessmentSex FactorsSexual BehaviorUganda

Identifiers

PMID25104262
PMCPMC4129546
OpenAlexW2129973721

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.