Evidence map›Paper›PMID 25104210›Full record

ReviewThrombosis and haemostasis2014

Tissue factor, protease activated receptors and pathologic heart remodelling.

Silvio Antoniak, Erica Sparkenbaugh, Rafal Pawlinski

Open access · greenAbstract readReview
In one paragraph

Review in Thrombosis and haemostasis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Frontiers in nutrition · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. The coagulation system in host defense.Research and practice in thrombosis and haemostasis · 2018
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Silvio Antoniak
Erica Sparkenbaugh
Rafal PawlinskiRafal Pawlinski, PhD, Division of Hematology/Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina, 320A Mary Ellen Jones Bldg, 98 Manning Drive, Chapel Hill, NC 27599, USA, Tel: 919 843 8387, Fax: 919 843 4896, E-mail: rafal_pawlinski@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

The Role of Tissue Factor: FVIIa-PAR-2 Signaling in Heart Ischemia/ReperfusionR01HL096679 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PAWLINSKI, RAFAL L · 2011 to 2015
$1.8M
The role of factor Xa and PAR2 in inflammation and pulmonary hypertension in sickF32HL121990 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SPARKENBAUGH, ERICA M · 2014 to 2015
$77k
NHLBI NIH HHS F32 HL121990NHLBI NIH HHS HL096679NHLBI NIH HHS HL121990-01NHLBI NIH HHS R01 HL096679
6 · The paper itself

Abstract

Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.

Indexed as

AnimalsBlood Coagulation FactorsFibrosisHeart Valve DiseasesHemostasisHumansHypertensionHypertension, PulmonaryHypertrophyModels, CardiovascularMyocardial InfarctionMyocarditisMyocytes, CardiacReceptors, Proteinase-ActivatedRenin-Angiotensin SystemThromboplastinBlood Coagulation FactorsReceptors, Proteinase-ActivatedThromboplastin

Identifiers

PMID25104210
PMCPMC4382753
OpenAlexW2066505458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.