ArticleInternational journal of radiation oncology, biology, physics2014
Toward distinguishing recurrent tumor from radiation necrosis: DWI and MTC in a Gamma Knife--irradiated mouse glioma model.
Article in International journal of radiation oncology, biology, physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Preclinical dose assessment of cyberknife with small animal intracranial irradiation using a 3D printed mouse phantom.Scientific reports · 2025Article
- Post-chemo-radiotherapy response and pseudo-progression evaluation on glioma cell types by multi-parametric magnetic resonance imaging: a prospective study.BMC medical imaging · 2023Article
- Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model.International journal of radiation oncology, biology, physics · 2022Article
- Distinguishing Tumor Admixed in a Radiation Necrosis (RN) Background:Frontiers in oncology · 2022Article
- Establishment and Validation of CyberKnife Irradiation in a Syngeneic Glioblastoma Mouse Model.Cancers · 2021Article
- Dynamic Three-Dimensional ADC Changes of Parotid Glands During Radiotherapy Predict the Salivary Secretary Function in Patients With Head and Neck Squamous Carcinoma.Frontiers in oncology · 2021Article
- Irradiation-Modulated Murine Brain Microenvironment Enhances GL261-Tumor Growth and Inhibits Anti-PD-L1 Immunotherapy.Frontiers in oncology · 2021Article
- Impact of mouse strain and sex when modeling radiation necrosis.Radiation oncology (London, England) · 2020Article
- Minimal difference between fractionated and single-fraction exposure in a murine model of radiation necrosis.Radiation oncology (London, England) · 2019Article
- Magnetic resonance imaging-guided radiation therapy using animal models of glioblastoma.The British journal of radiology · 2019Review
- Preclinical MRI: Studies of the irradiated brain.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model.International journal of radiation biology · 2017Article
- Can anti-vascular endothelial growth factor antibody reverse radiation necrosis? A preclinical investigation.Journal of neuro-oncology · 2017Article
- A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-Gaussian diffusion MRI.Magnetic resonance imaging · 2017Article
- A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.Journal of neuro-oncology · 2016Article
- Specificity of vascular endothelial growth factor treatment for radiation necrosis.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2015Article
- Perilesional edema in radiation necrosis reflects axonal degeneration.Radiation oncology (London, England) · 2015Article
- A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.PloS one · 2015Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeAccurate noninvasive diagnosis is vital for effective treatment planning. Presently, standard anatomical magnetic resonance imaging (MRI) is incapable of differentiating recurring tumor from delayed radiation injury, as both lesions are hyperintense in both postcontrast T1- and T2-weighted images. Further studies are therefore necessary to identify an MRI paradigm that can differentially diagnose these pathologies. Mouse glioma and radiation injury models provide a powerful platform for this purpose. METHODS AND MATERIALS: Two MRI contrasts that are widely used in the clinic were chosen for application to a glioma/radiation-injury model: diffusion weighted imaging, from which the apparent diffusion coefficient (ADC) is obtained, and magnetization transfer contrast, from which the magnetization transfer ratio (MTR) is obtained. These metrics were evaluated longitudinally, first in each lesion type alone-glioma versus irradiation - and then in a combined irradiated glioma model.
resultsMTR was found to be consistently decreased in all lesions compared to nonlesion brain tissue (contralateral hemisphere), with limited specificity between lesion types. In contrast, ADC, though less sensitive to the presence of pathology, was increased in radiation injury and decreased in tumors. In the irradiated glioma model, ADC also increased immediately after irradiation, but decreased as the tumor regrew.
conclusionsADC is a better metric than MTR for differentiating glioma from radiation injury. However, MTR was more sensitive to both tumor and radiation injury than ADC, suggesting a possible role in detecting lesions that do not enhance strongly on T1-weighted images.
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