ArticleInternational journal of radiation oncology, biology, physics2014
Pulmonary ventilation imaging based on 4-dimensional computed tomography: comparison with pulmonary function tests and SPECT ventilation images.
Article in International journal of radiation oncology, biology, physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Incorporation of Functional Lung Imaging Into Radiation Therapy Planning in Patients With Lung Cancer: A Systematic Review and Meta-Analysis.International journal of radiation oncology, biology, physics · 2024Pooled it
- Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta-analysis.Scientific reports · 2020Pooled it
- Interim Analysis of a Two-Institution, Prospective Clinical Trial of 4DCT-Ventilation-based Functional Avoidance Radiation Therapy.International journal of radiation oncology, biology, physics · 2018Trial
- Antifibrotic monocyte activation by nanoparticles resolves murine pulmonary fibrosis.Biomaterials · 2026Article
- Predicting End-of-Treatment Ventilation Response to Radiation Therapy Using Early Treatment Ventilation for Patients With Lung Cancer Treated With Photons and Protons.International journal of radiation oncology, biology, physics · 2026Article
- Pulmonary ventilation images from planning CT images using deep learning on locally-advanced NSCLC patients.Journal of applied clinical medical physics · 2026Article
- Functional lung avoidance proton radiation therapy planning using anatomy-wise computed tomography-derived lung ventilation imaging.Radiation oncology (London, England) · 2026Article
- Clinical validation of perfusion imaging with pulmonary function test data using Voronoi-based discretization.Physics in medicine and biology · 2026Article
- Simultaneous synthesis of perfusion and ventilation images from CT using a dual-decoder residual attention network for lung disease diagnosis.Journal of applied clinical medical physics · 2026Article
- A novel method for generating a fused ventilation-perfusion map using CT-derived ventilation and FDG-PET for lung functional avoidance in radiotherapy: A feasibility study.Precision radiation oncology · 2026Article
- Four-Dimensional Computed Tomography of Respiratory Function Changes Post-Radiotherapy for Lung Cancer.Cureus · 2026Article
- Four-dimensional computed tomography ventilation imaging-guided radiotherapy planning in different techniques for lung cancer.Frontiers in oncology · 2026Article
- Relevance between patients' clinical factors and 4D-CT lung ventilation heterogeneity for evaluating the adoption of functional avoidance thoracic radiotherapy with a large patient database.Frontiers in oncology · 2026Article
- Weekly changes in ventilation response for photon and proton lung cancer patients during radiotherapy.medRxiv : the preprint server for health sciences · 2025Article
- Hybrid method for estimating lung ventilation from CT by combining intensity and motion information.Medical physics · 2025Article
- Assessing the consistency of CT-based ventilation imaging under noise reduction processing with simulated quantum noise using a nonrigid alveoli phantom.Frontiers in radiology · 2025Article
- Motion and anatomy dual aware lung ventilation imaging by integrating Jacobian map and average CT image using dual path fusion network.Medical physics · 2025Article
- A review on functional lung avoidance radiotherapy plan for lung cancer.Frontiers in oncology · 2024Review
- Advances in CT-based lung function imaging for thoracic radiotherapy.Frontiers in oncology · 2024Review
- Assessing four-dimensional CT stress maps derived from patient-specific biomechanical models of the lung with pulmonary function test data in lung cancer patients.The British journal of radiology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
purpose4-dimensional computed tomography (4D-CT)-based pulmonary ventilation imaging is an emerging functional imaging modality. The purpose of this study was to investigate the physiological significance of 4D-CT ventilation imaging by comparison with pulmonary function test (PFT) measurements and single-photon emission CT (SPECT) ventilation images, which are the clinical references for global and regional lung function, respectively. METHODS AND MATERIALS: In an institutional review board-approved prospective clinical trial, 4D-CT imaging and PFT and/or SPECT ventilation imaging were performed in thoracic cancer patients. Regional ventilation (V4DCT) was calculated by deformable image registration of 4D-CT images and quantitative analysis for regional volume change. V4DCT defect parameters were compared with the PFT measurements (forced expiratory volume in 1 second (FEV1; % predicted) and FEV1/forced vital capacity (FVC; %). V4DCT was also compared with SPECT ventilation (VSPECT) to (1) test whether V4DCT in VSPECT defect regions is significantly lower than in nondefect regions by using the 2-tailed t test; (2) to quantify the spatial overlap between V4DCT and VSPECT defect regions with Dice similarity coefficient (DSC); and (3) to test ventral-to-dorsal gradients by using the 2-tailed t test.
resultsOf 21 patients enrolled in the study, 18 patients for whom 4D-CT and either PFT or SPECT were acquired were included in the analysis. V4DCT defect parameters were found to have significant, moderate correlations with PFT measurements. For example, V4DCT(HU) defect volume increased significantly with decreasing FEV1/FVC (R=-0.65, P<.01). V4DCT in VSPECT defect regions was significantly lower than in nondefect regions (mean V4DCT(HU) 0.049 vs 0.076, P<.01). The average DSCs for the spatial overlap with SPECT ventilation defect regions were only moderate (V4DCT(HU)0.39 ± 0.11). Furthermore, ventral-to-dorsal gradients of V4DCT were strong (V4DCT(HU) R(2) = 0.69, P=.08), which was similar to VSPECT (R(2) = 0.96, P<.01).
conclusionsAn 18-patient study demonstrated significant correlations between 4D-CT ventilation and PFT measurements as well as SPECT ventilation, providing evidence toward the validation of 4D-CT ventilation imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.