ArticleJournal of bioenergetics and biomembranes2015
Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure.
Article in Journal of bioenergetics and biomembranes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Potential for Ketotherapies as Amyloid-Regulating Treatment in Individuals at Risk for Alzheimer's Disease.Frontiers in neuroscience · 2022Review
- A 1-Month Ketogenic Diet Increased Mitochondrial Mass in Red Gastrocnemius Muscle, but Not in the Brain or Liver of Middle-Aged Mice.Nutrients · 2021Article
- A ketogenic diet differentially affects neuron and astrocyte transcription.Journal of neurochemistry · 2021Article
- A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice.Aging · 2021Article
- Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer's Disease.Journal of personalized medicine · 2020Review
- Dietary Neuroketotherapeutics for Alzheimer's Disease: An Evidence Update and the Potential Role for Diet Quality.Nutrients · 2019Review
- ENOblock inhibits the pathology of diet-induced obesity.Scientific reports · 2019Article
- Neuroketotherapeutics: A modern review of a century-old therapy.Neurochemistry international · 2018Review
- Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2018Article
- A bioenergetics systems evaluation of ketogenic diet liver effects.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2017Article
- New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.Current pharmaceutical design · 2017Review
- A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.Neurobiology of aging · 2016Article
- Isocaloric high-fat feeding directs hepatic metabolism to handling of nutrient imbalance promoting liver fat deposition.International journal of obesity (2005) · 2016Article
- Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease.Current topics in medicinal chemistry · 2016Review
- Metabolomic Analysis in Brain Research: Opportunities and Challenges.Frontiers in physiology · 2016Article
- High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death.BMC neuroscience · 2015Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Diet composition may affect energy metabolism in a tissue-specific manner. Using C57Bl/6J mice, we tested the effect of ketosis-inducing and non-inducing high fat diets on genes relevant to brain bioenergetic infrastructures, and on proteins that constitute and regulate that infrastructure. At the end of a one-month study period the two high fat diets appeared to differentially affect peripheral insulin signaling, but brain insulin signaling was not obviously altered. Some bioenergetic infrastructure parameters were similarly impacted by both high fat diets, while other parameters were only impacted by the ketogenic diet. For both diets, mRNA levels for CREB, PGC1α, and NRF2 increased while NRF1, TFAM, and COX4I1 mRNA levels decreased. PGC1β mRNA increased and TNFα mRNA decreased only with the ketogenic diet. Brain mtDNA levels fell in both the ketogenic and non-ketogenic high fat diet groups, although TOMM20 and COX4I1 protein levels were maintained, and mRNA and protein levels of the mtDNA-encoded COX2 subunit were also preserved. Overall, the pattern of changes observed in mice fed ketogenic and non-ketogenic high fat diets over a one month time period suggests these interventions enhance some aspects of the brain's aerobic infrastructure, and may enhance mtDNA transcription efficiency. Further studies to determine which diet effects are due to changes in brain ketone body levels, fatty acid levels, glucose levels, altered brain insulin signaling, or other factors such as adipose tissue-associated hormones are indicated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.