ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Acute Blood Pressure Response to Different Types of Isometric Exercise: A Systematic Review with Meta-Analysis.Reviews in cardiovascular medicine · 2023Pooled it
- Sources of inaccuracy in the measurement of adult patients' resting blood pressure in clinical settings: a systematic review.Journal of hypertension · 2017Pooled it
- The Japanese Society of Hypertension Practical Consensus Guidelines for Seasonal Blood Pressure Management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis.BMC public health · 2026Article
- Cardiovascular and Thermal Responses to Cold Exposure During Exercise in Iron-Deficient Anemic Individuals.Journal of functional morphology and kinesiology · 2025Article
- Cardiovascular responses to heat and cold exposure are altered by preterm birth in guinea pigs.Physiological reports · 2024Article
- Using Wavelet Analysis of Blood Flow Oscillations to Investigate Differences in Skin Blood Flow Regulations Between the Upper and Lower Limbs.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Senior Health in a Changing Climate: Unique Needs of a Complex Population.Environmental health perspectives · 2024Article
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance.Experimental physiology · 2023Article
- Baroreflex sensitivity following acute upper-body exercise in the cold among stable coronary artery disease patients.Frontiers in physiology · 2023Article
- Cardiovascular responses to dynamic and static upper-body exercise in a cold environment in coronary artery disease patients.European journal of applied physiology · 2022Article
- Contrast-Enhanced Ultrasonography Enables the Detection of a Cold Pressor Test-Induced Increase in Renal Microcirculation in Healthy Participants.Frontiers in cardiovascular medicine · 2022Article
- Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men.Scientific reports · 2021Article
- Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults.Physiological reports · 2021Article
- Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow.European journal of applied physiology · 2020Review
- Associations between Ambient Temperature and Acute Myocardial Infarction.Open medicine (Warsaw, Poland) · 2019Article
- Cardiovascular diseases, cold exposure and exercise.Temperature (Austin, Tex.) · 2018Review
- Sympathetic function during whole body cooling is altered in hypertensive adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular mortality increases in cold weather in older adults, and physical activity may impart even greater cardiovascular risk than cold exposure alone. Human aging is associated with exaggerated pressor responses to whole body cooling; however, the sympathetic response to cold stress alone and in combination with isometric exercise is unknown. We hypothesized that cold stress would 1) increase muscle sympathetic nerve activity (MSNA) and 2) augment the MSNA response to isometric handgrip in older adults. Whole body cooling (water-perfused suit) was conducted in 11 young (23 ± 1 yr) and 12 healthy older adults (60 ± 2 yr). Blood pressure (BP; Finometer) and MSNA (microneurography) were measured throughout cooling and during isometric handgrip at 30% maximal voluntary contraction performed at a mean skin temperature (Tsk) of 34 and 30.5°C. MSNA was greater in older adults at Tsk = 34.0°C and throughout cooling (P < 0.05). MSNA increased during cooling in older, but not young, adults (young: Δ0 ± 1 vs. older: Δ8 ± 1 bursts/min; P < 0.05). The cooling-induced increase in BP was greater in older adults (P < 0.05). During handgrip, the increases in MSNA and BP were not different between conditions in either young (Δ14 ± 2 Tsk 34°C vs. Δ12 ± 3 Tsk 30.5°C bursts/min; Δ20 ± 3 Tsk 34°C vs. Δ19 ± 3 Tsk 30.5°C mmHg; both P > 0.05) or older adults (Δ12 ± 1 Tsk 34°C vs. Δ8 ± 1 Tsk 30.5°C bursts/min; Δ18 ± 3 Tsk 34°C vs. Δ17 ± 2 Tsk 30.5°C mmHg; both P > 0.05). In summary, MSNA increased during cold stress in older, but not young, adults. Furthermore, concomitant cold stress did not alter the sympathetic responses to isometric exercise in either age group, suggesting preserved sympathetic responsiveness during exercise in the cold in healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.