ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Polymorphisms in miRNA Genes Targeting the AMPK Signaling Pathway are Associated with Cervical Cancer Susceptibility in a Han Chinese Population.International journal of general medicine · 2024Article
- Genetic Regulation of Human isomiR Biogenesis.Cancers · 2023Article
- Cervical Cancer Stem-Like Cell Transcriptome Profiles Predict Response to Chemoradiotherapy.Frontiers in oncology · 2021Article
- Article
- miR-486 as an unfavorable prognostic biomarker for patients with non-small cell lung cancer.Translational cancer research · 2020Article
- Bayesian variable selection for parametric survival model with applications to cancer omics data.Human genomics · 2018Article
- MiRNA Polymorphisms and Cancer Prognosis: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2018Article
- Genetic variant of miR-4293 rs12220909 is associated with susceptibility to non-small cell lung cancer in a Chinese Han population.PloS one · 2017Article
- Potential Mechanisms Underlying TGF-β-mediated Complement Activation in Lung Fibrosis.Cellular & molecular medicine: open access · 2017Article
- MiRNAs and miRNA Polymorphisms Modify Drug Response.International journal of environmental research and public health · 2016Review
- Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.Oncotarget · 2015Article
- Correlation of genetic polymorphism of vascular endothelial growth factor gene with susceptibility to lung cancer.Cancer gene therapy · 2015Article
- miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung adenocarcinoma cells.Cancer gene therapy · 2015Article
- The association between SDF-1 G801A polymorphism and non-small cell lung cancer risk in a Chinese Han population.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundMicroRNAs (miRNA) play important roles in the regulation of eukaryotic gene expression and are involved in human carcinogenesis. Single-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in turn, may affect cancer risk and disease progression.
methodsWe conducted an analysis of associations of 142 miRNA SNPs with non-small cell lung cancer (NSCLC) survival using data from a genome-wide association study (GWAS) in a Caucasian population from the Massachusetts General Hospital (Boston, MA) including 452 early-stage and 526 late-stage NSCLC cases. Replication analyses were further performed in two external populations, one Caucasian cohort from The University of Texas MD Anderson Cancer Center (Houston, TX) and one Han Chinese cohort from Nanjing, China.
resultsWe identified seven significant SNPs in the discovery set. Results from the independent Caucasian cohort demonstrated that the C allele of rs2042253 (hsa-miRNA-5197) was significantly associated with decreased risk for death among the patients with late-stage NSCLC (discovery set: HR, 0.80; P = 0.007; validation set: HR, 0.86; P = 0.035; combined analysis: HR, 0.87; P = 0.007).
conclusionsThese findings provide evidence that some miRNA SNPs are associated with NSCLC survival and can be used as predictive biomarkers. IMPACT: This study provided an estimate of outcome probability for survival experience of patients with NSCLC, which demonstrates that genetic factors, as well as classic nongenetic factors, may be used to predict individual outcome.
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