ArticleInvestigative ophthalmology & visual science2014
Magic angle-enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 53 citations in OpenAlex.
- Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.Science advances · 2025Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- A review of the epithelial and stromal effects of corneal collagen crosslinking.The ocular surface · 2023Review
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Stretch-Induced Uncrimping of Equatorial Sclera Collagen Bundles.Journal of biomechanical engineering · 2023Article
- Simultaneous Assessment of the Whole Eye Biomechanics Using Ultrasonic Elastography.IEEE transactions on bio-medical engineering · 2023Article
- Causal association between common rheumatic diseases and glaucoma: a Mendelian randomization study.Frontiers in immunology · 2023Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- Finite element modeling of the complex anisotropic mechanical behavior of the human sclera and pia mater.Computer methods and programs in biomedicine · 2022Article
- 3T high-resolution magnetic resonance imaging, conventional ultrasonography and ultrasound biomicroscopy of the normal canine eye.BMC veterinary research · 2022Article
- Role of Structural, Metabolic, and Functional MRI in Monitoring Visual System Impairment and Recovery.Journal of magnetic resonance imaging : JMRI · 2021Review
- Stress-Strain Index Map: A New Way to Represent Corneal Material Stiffness.Frontiers in bioengineering and biotechnology · 2021Article
- Multi-parametric MRI of the physiology and optics of the in-vivo mouse lens.Magnetic resonance imaging · 2020Article
- A Mesh-Free Approach to Incorporate Complex Anisotropic and Heterogeneous Material Properties into Eye-Specific Finite Element Models.Computer methods in applied mechanics and engineering · 2020Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- Magnetic Resonance Conditional Microinjector.Journal of imaging · 2018Article
- Collagen fiber crimping following in vivo UVA-induced corneal crosslinking.Experimental eye research · 2018Article
- Radial and Circumferential Collagen Fibers Are a Feature of the Peripapillary Sclera of Human, Monkey, Pig, Cow, Goat, and Sheep.Investigative ophthalmology & visual science · 2018Article
- Crimp around the globe; patterns of collagen crimp across the corneoscleral shell.Experimental eye research · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeThe structure and biomechanics of the sclera and cornea are central to several eye diseases such as glaucoma and myopia. However, their roles remain unclear, partly because of limited noninvasive techniques to assess their fibrous microstructures globally, longitudinally, and quantitatively. We hypothesized that magic angle-enhanced magnetic resonance imaging (MRI) can reveal the structural details of the corneoscleral shell and their changes upon intraocular pressure (IOP) elevation.
methodsSeven ovine eyes were extracted and fixed at IOP = 50 mm Hg to mimic ocular hypertension, and another 11 eyes were unpressurized. The sclera and cornea were scanned at different angular orientations relative to the main magnetic field inside a 9.4-Tesla MRI scanner. Relative MRI signal intensities and intrinsic transverse relaxation times (T2 and T2*) were determined to quantify the magic angle effect on the corneoscleral shells. Three loaded and eight unloaded tendon samples were scanned as controls.
resultsAt magic angle, high-resolution MRI revealed distinct scleral and corneal lamellar fibers, and light/dark bands indicative of collagen fiber crimps in the sclera and tendon. Magic angle enhancement effect was the strongest in tendon and the least strong in cornea. Loaded sclera, cornea, and tendon possessed significantly higher T2 and T2* than unloaded tissues at magic angle.
conclusionsMagic angle-enhanced MRI can detect ocular fibrous microstructures without contrast agents or coatings and can reveal their MR tissue property changes with IOP loading. This technique may open up new avenues for assessment of the biomechanical and biochemical properties of ocular tissues in aging and in diseases involving the corneoscleral shell.
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