ArticleMolecular biology of the cell2014
Actin cable distribution and dynamics arising from cross-linking, motor pulling, and filament turnover.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Polarity sorting of actin filaments by motor-driven cargo transport.Biophysical journal · 2025Article
- Discrete mechanical model of lamellipodial actin network implements molecular clutch mechanism and generates arcs and microspikes.PLoS computational biology · 2021Article
- Formin Cdc12's specific actin assembly properties are tailored for cytokinesis in fission yeast.Biophysical journal · 2021Article
- Microtubule-independent movement of the fission yeast nucleus.Journal of cell science · 2021Article
- Two- and Three-Dimensional Tracking ofCells · 2020Article
- Organization of associating or crosslinked actin filaments in confinement.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Multiscale model of integrin adhesion assembly.PLoS computational biology · 2019Article
- Automated Tracking of Biopolymer Growth and Network Deformation with TSOAX.Scientific reports · 2019Article
- Mechanisms of formin-mediated actin assembly and dynamics.Biophysical reviews · 2018Review
- Microtubule Dynamics, Kinesin-1 Sliding, and Dynein Action Drive Growth of Cell Processes.Biophysical journal · 2018Article
- Structural organization and energy storage in crosslinked actin assemblies.PLoS computational biology · 2018Article
- Cell-wall remodeling drives engulfment duringeLife · 2016Article
- MEDYAN: Mechanochemical Simulations of Contraction and Polarity Alignment in Actomyosin Networks.PLoS computational biology · 2016Article
- A Combination of Actin Treadmilling and Cross-Linking Drives Contraction of Random Actomyosin Arrays.Biophysical journal · 2015Article
- Computational model of polarized actin cables and cytokinetic actin ring formation in budding yeast.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Geometrical and mechanical properties control actin filament organization.PLoS computational biology · 2015Article
- Dynamic network morphology and tension buildup in a 3D model of cytokinetic ring assembly.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The growth of fission yeast relies on the polymerization of actin filaments nucleated by formin For3p, which localizes at tip cortical sites. These actin filaments bundle to form actin cables that span the cell and guide the movement of vesicles toward the cell tips. A big challenge is to develop a quantitative understanding of these cellular actin structures. We used computer simulations to study the spatial and dynamical properties of actin cables. We simulated individual actin filaments as semiflexible polymers in three dimensions composed of beads connected with springs. Polymerization out of For3p cortical sites, bundling by cross-linkers, pulling by type V myosin, and severing by cofilin are simulated as growth, cross-linking, pulling, and turnover of the semiflexible polymers. With the foregoing mechanisms, the model generates actin cable structures and dynamics similar to those observed in live-cell experiments. Our simulations reproduce the particular actin cable structures in myoVΔ cells and predict the effect of increased myosin V pulling. Increasing cross-linking parameters generates thicker actin cables. It also leads to antiparallel and parallel phases with straight or curved cables, consistent with observations of cells overexpressing α-actinin. Finally, the model predicts that clustering of formins at cell tips promotes actin cable formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.