ArticleSchizophrenia bulletin2015
The impact of aging, cognition, and symptoms on functional competence in individuals with schizophrenia across the lifespan.
Article in Schizophrenia bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Exploring the Relationship between Cognitive Performance, Performance-Based Functioning, and Everyday Functioning in People with Schizophrenia: a Systematic Literature Review.Schizophrenia bulletin · 2026Pooled it
- Assessing the Effect of Food on the Pharmacokinetics of Iclepertin in Healthy Volunteers: A Phase I, Open-Label, Randomised, Cross-over Trial.European journal of drug metabolism and pharmacokinetics · 2025Trial
- Efficacy of Cortical-Hippocampal Target Intermittent Theta Burst Stimulation (iTBS) on Associative Memory of Schizophrenia: A Double-Blind, Randomized Sham-Controlled Trial.Neuropsychiatric disease and treatment · 2024Trial
- UPSA-M: Feasibility and initial validity of a mobile application of the UCSD Performance-Based Skills Assessment.Schizophrenia research · 2015Trial
- The Effect of Multiple Oral Doses of a Glycine Transporter 1 Inhibitor, Iclepertin (BI 425809), on the Steady-state Pharmacokinetics of a Combined Oral Contraceptive Containing Ethinylestradiol and Levonorgestrel: a Phase I Clinical Trial in Healthy Females.Clinical drug investigation · 2025Article
- Physical health challenges faced by elders with severe mental illness: population-based retrospective cohort study.BJPsych open · 2024Article
- Study investigating executive function in schizophrenia patients and their unaffected siblings.PloS one · 2023Article
- The Impact of Anticholinergic Burden on Functional Capacity in Persons With Schizophrenia Across the Adult Life Span.Schizophrenia bulletin · 2021Article
- The Impact of Negative Symptoms and Neurocognition on Functioning in MDD and Schizophrenia.Frontiers in psychiatry · 2021Article
- Decreased Peripheral BDNF Levels and Cognitive Impairment in Late-Life Schizophrenia.Frontiers in psychiatry · 2021Article
- Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia.Translational psychiatry · 2020Article
- Article
- Metacognitive preserved generation strategy benefits for both younger and elderly participants with schizophrenia.PloS one · 2020Article
- The Optimal Length of Hospitalization for Functional Recovery of Schizophrenia Patients, a Real-World Study in Chinese People.The Psychiatric quarterly · 2019Article
- Superior memory performance in healthy individuals with subclinical psychotic symptoms but without genetic load for schizophrenia.Schizophrenia research. Cognition · 2018Article
- Predictors of current functioning and functional decline in schizophrenia.Schizophrenia research · 2017Article
- Article
- Cognitive Functioning in Older Adults With Schizophrenia.Focus (American Psychiatric Publishing) · 2017Review
- Cognition and Dopamine DThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Article
- Technology to assess and support self-management in serious mental illness.Dialogues in clinical neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveLife expectancy in individuals with schizophrenia continues to increase. It is not clear whether cognitive deficits associated with schizophrenia remain as strong predictors of function in older and younger individuals. Thus, we assessed the relationship between cognition and functional competence in individuals with schizophrenia across 7 decades of life.
methodsWe analyzed data obtained in 232 community-dwelling participants with schizophrenia (age range: 19-79 years). Cognition was assessed using the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery. Functional competence was assessed using the UCSD Performance-based Skills Assessment, which includes measures of Comprehension and Planning of Recreational Activities Skills, Financial Skills, Communication Skills, Transportation Skills, and Household Management Skills. To assess the effects of Global Cognition on functional competence, we performed hierarchical multivariate linear or logistic regression analyses controlling for age, education, gender, and negative symptoms.
resultsParticipants' mean age was 49.1 (SD = 13.2, range = 19-79 years), 161 (69%) were male, and 55 (24%) were aged ≥60. Global Cognition was a predictor of Comprehension and Planning Skills (Exp(β) = 1.048), Financial Skills (Exp(β) = 1.104), Communication Skills (ΔR (2) = .31) and Transportation Skills (Exp(β) = 1.066), but not Household Management Skills after adjusting for age, education, gender, and negative symptoms of schizophrenia.
conclusionCognition remains a strong predictor of functional competence across the lifespan. These findings suggest that treating cognitive impairment associated with schizophrenia could improve individuals' function independent of their age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.