ArticleMycopathologia2014
Nosocomial bloodstream Candida infections in a tertiary-care hospital in South Brazil: a 4-year survey.
Article in Mycopathologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 38 citations in OpenAlex.
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- Prevalence and Species Distribution ofJournal of fungi (Basel, Switzerland) · 2024Article
- Advanced genetic techniques in fungal pathogen research.mSphere · 2024Review
- Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated from Candidemia.Mycopathologia · 2021Article
- Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres.eLife · 2020Article
- Phenotypic switching in Candida tropicalis alters host-pathogen interactions in a Galleria mellonella infection model.Scientific reports · 2019Article
- How much do we know about hemolytic capability of pathogenic Candida species?Folia microbiologica · 2018Review
- An Azole-ResistantFrontiers in microbiology · 2018Article
- Revisiting Species Distribution and Antifungal Susceptibility of Candida Bloodstream Isolates from Latin American Medical Centers.Journal of fungi (Basel, Switzerland) · 2017Review
- Phenotypic switching of Candida tropicalis is associated with cell damage in epithelial cells and virulence in Galleria mellonella model.Virulence · 2016Article
- The identification and differentiation of the Candida parapsilosis complex species by polymerase chain reaction-restriction fragment length polymorphism of the internal transcribed spacer region of the rDNA.Memorias do Instituto Oswaldo Cruz · 2016Article
- Resistance Surveillance in Candida albicans: A Five-Year Antifungal Susceptibility Evaluation in a Brazilian University Hospital.PloS one · 2016Article
- Effects of human blood red cells on the haemolytic capability of clinical isolates of Candida tropicalis.Journal of biomedical science · 2015Article
- Extracellular hydrolytic enzyme activities of the differentJournal of laboratory physiciansArticle
- Simvastatin inhibits planktonic cells and biofilms of Candida and Cryptococcus species.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were to evaluate the epidemiology of nosocomial candidemia in a tertiary hospital in South Brazil and the in vitro antifungal susceptibility of isolates. Blood strains from 108 patients were identified by PCR-based method. Some 30.5 % of candidemia were caused by Candida tropicalis, 28.7 % were due to Candida albicans, 24.1 % with Candida parapsilosis sensu stricto, 8.3 % with Candida glabrata sensu lato, 1.8 % involved Candida krusei and 6.6 % with other species. Candidemia was more common in intensive care unit settings (66 %). In vitro susceptibility to antifungal drugs was determined by a microdilution method; and new species-specific clinical breakpoints for fluconazole and voriconazole were applied. Overall susceptibility rates were 100 % for itraconazole, 91 % for fluconazole, 98 % for voriconazole and 99 % for amphotericin B. Fluconazole resistance was mostly among C. parapsilosis sensu stricto isolates (26.9 %). Most of the findings reported here agreed with epidemiological features common to other tertiary hospitals in Brazil; but also revealed some peculiarities, such as a high frequency of C. tropicalis associated with candidemia. Besides, high rate of fluconazole resistance among C. parapsilosis stricto sensu isolates was obtained when applying the new species-specific clinical breakpoints.
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