ArticleDigestive diseases and sciences2015
Impact of microscopic duodenitis on symptomatic response to Helicobacter pylori eradication in functional dyspepsia.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- The prevalence of functional dyspepsia using Rome IV questionnaire among chronic kidney disease patients.Renal failure · 2024Observational
- Functional Dyspepsia: A Narrative Review With a Focus on Sex-Gender Differences.Journal of neurogastroenterology and motility · 2020Review
- AdhesiveFrontiers in microbiology · 2019Article
- IsJournal of neurogastroenterology and motility · 2017Review
- Helicobacter pylori-Associated Upper Gastrointestinal Symptoms: FD or HpD?Digestive diseases and sciences · 2017Article
- Factors Related to Upper Gastrointestinal Symptom Generation in 2275 Helicobacter pylori Seroprevalent Adults.Digestive diseases and sciences · 2017Article
- RELATIONSHIP BETWEEN THE PRESENCE OF HELICOBACTER PYLORI WITH INFLAMMATORY ENDOSCOPIC CHANGES IN GASTRODUODENAL MUCOSA.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgeryObservational
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimThere is no consensus regarding the benefit of eradicating Helicobacter pylori (H. pylori) infection in patients with functional dyspepsia (FD). We intended to compare the symptom response to H. pylori eradication in FD patients in presence or absence of microscopic duodenitis (MD).
methodsPatients with dyspepsia, normal upper gastrointestinal endoscopy and no psychological comorbidity according to the 12-item General Health Questionnaire underwent duodenal biopsy sampling. Of those, subjects with positive rapid urease test and H. pylori colonization in Wright-Giemsa staining were included in the study and evaluated histologically for presence of MD. All patients received sequential H. pylori eradication therapy and underwent urea breath test 4 weeks after the completion of the treatment to confirm the H. pylori eradication. The severity of dyspepsia was assessed using the Leeds Dyspepsia Questionnaire (LDQ) at baseline, 3rd and 6th months after the H. pylori infection was eradicated.
resultsThirty seven patients were included in the study [mean age: 34.9 (8.1), 54.05 % female]. MD was observed in 16 (43.2 %) of the subjects. The mean LDQ score in patients with MD decreased from 12.5 (4.1) at baseline to 4.3 (2.1) at 3rd month and 2.6 (1.9) at 6th month. In patients without microscopic duodenitis, the mean LDQ score decreased from 10.6 (5.2) at baseline to 6.8 (4.1) and 6.2 (3.8) at 3rd and 6th months, respectively. The improvement in severity of symptoms in presence of MD was significantly greater than when it was absent (P < 0.001).
conclusionFD patients with MD achieved greater symptomatic response with H. pylori eradication than those without microscopic duodenitis.
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