Evidence map›Paper›PMID 25102947›Full record

Trial reportLeukemia2014

Lymphodepletion followed by infusion of suicide gene-transduced donor lymphocytes to safely enhance their antitumor effect: a phase I/II study.

S Maury, M Rosenzwajg, R Redjoul, A Marcais, A Xhaard, M Cherai, L Cabanne, G Churlaud, F Suarez, G Socié and 11 more

Abstract readClinical Trial, Phase IClinical Trial, Phase IILetter
PubMed Publisher
In one paragraph

Trial report in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Regulatory T cells in the treatment of disease.Nature reviews. Drug discovery · 2018
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

S Maury1] AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France [2] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France [3] Center for Clinical Investigation in Biotherapy, Créteil, France.
M Rosenzwajg1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] AP-HP, Hôpital Pitié-Salpêtrière, Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France [4] Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France [5] INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France.
R RedjoulAP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France.
A MarcaisDepartment of Hematology, Hôpital Necker, Paris, France.
A XhaardDepartment of Hematology-Transplantation, Hôpital St Louis, Paris, France.
M Cherai1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France.
L CabanneAP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France.
G ChurlaudAP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France.
F SuarezDepartment of Hematology, Hôpital Necker, Paris, France.
G SociéDepartment of Hematology-Transplantation, Hôpital St Louis, Paris, France.
L GregoireDepartment of Public Health, Créteil, France.
K DebbacheAP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France.
C Bernard1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] AP-HP, Hôpital Pitié-Salpêtrière, Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France.
J-L BeaumontDepartment of Hemapheresis, Etablissement Français du Sang, Créteil, France.
N AzarAP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France.
O BoyerSorbonne Universités, UPMC Univ Paris 06, UMR-S INSERM 1135, CIMI-Paris, Paris, France.
F Roudot-Thoraval1] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France [2] Department of Public Health, Créteil, France.
J L Cohen1] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France [2] Center for Clinical Investigation in Biotherapy, Créteil, France.
C Cordonnier1] AP-HP, Hôpital Henri Mondor, Department of Hematology, DHU Virus-Immunity-Cancer, Créteil, France [2] IMRB, University Paris Est Créteil (UPEC), INSERM U955 team 21, Créteil, France.
F M Lemoine1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] Sorbonne Universités, UPMC Univ Paris 06, UMR-S INSERM 1135, CIMI-Paris, Paris, France.
D Klatzmann1] AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy Department, Paris, France [2] AP-HP, Hôpital Pitié-Salpêtrière, Clinical Investigation Center in Biotherapy (CIC-BTi), Paris, France [3] AP-HP, Hôpital Pitié-Salpêtrière, Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, France [4] Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France [5] INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genes, Transgenic, SuicideGenetic TherapyImmunotherapy, AdoptiveGraft vs Host DiseaseHumansLymphocyte DepletionLymphocytesNeoplasmsTissue DonorsTransduction, GeneticTreatment Outcome

Identifiers

PMID25102947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.