ArticlePLoS genetics2014
Branch migration prevents DNA loss during double-strand break repair.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Overcoming the Speed Limit of Four-Way DNA Branch Migration with Bulges in Toeholds.Nano letters · 2025Article
- Isolation and purification of DNA double-strand break repair intermediates for understanding complex molecular mechanisms.PloS one · 2024Article
- Cryo-EM structure of the RuvAB-Holliday junction intermediate complex fromFrontiers in plant science · 2023Article
- The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops.Nature communications · 2022Article
- The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.PLoS genetics · 2021Article
- DisA Restrains the Processing and Cleavage of Reversed Replication Forks by the RuvAB-RecU Resolvasome.International journal of molecular sciences · 2021Article
- Distribution of Holliday junctions and repair forks during Escherichia coli DNA double-strand break repair.PLoS genetics · 2021Article
- DNA Repair and the Stability of the Plant Mitochondrial Genome.International journal of molecular sciences · 2020Review
- DNA double-strand break formation and repair as targets for novel antibiotic combination chemotherapy.Future science OA · 2019Review
- The positioning of Chi sites allows the RecBCD pathway to suppress some genomic rearrangements.Nucleic acids research · 2019Article
- Replication Fork Breakage and Restart in Escherichia coli.Microbiology and molecular biology reviews : MMBR · 2018Review
- RecBCD coordinates repair of two ends at a DNA double-strand break, preventing aberrant chromosome amplification.Nucleic acids research · 2018Article
- Replication Restart in Bacteria.Journal of bacteriology · 2017Review
- RecG controls DNA amplification at double-strand breaks and arrested replication forks.FEBS letters · 2017Review
- Escherichia coli RadD Protein Functionally Interacts with the Single-stranded DNA-binding Protein.The Journal of biological chemistry · 2016Article
- Irc3 is a mitochondrial DNA branch migration enzyme.Scientific reports · 2016Article
- RecG Directs DNA Synthesis during Double-Strand Break Repair.PLoS genetics · 2016Article
- The RECG1 DNA Translocase Is a Key Factor in Recombination Surveillance, Repair, and Segregation of the Mitochondrial DNA in Arabidopsis.The Plant cell · 2015Article
- Quantitative genomic analysis of RecA protein binding during DNA double-strand break repair reveals RecBCD action in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- RECG maintains plastid and mitochondrial genome stability by suppressing extensive recombination between short dispersed repeats.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The repair of DNA double-strand breaks must be accurate to avoid genomic rearrangements that can lead to cell death and disease. This can be accomplished by promoting homologous recombination between correctly aligned sister chromosomes. Here, using a unique system for generating a site-specific DNA double-strand break in one copy of two replicating Escherichia coli sister chromosomes, we analyse the intermediates of sister-sister double-strand break repair. Using two-dimensional agarose gel electrophoresis, we show that when double-strand breaks are formed in the absence of RuvAB, 4-way DNA (Holliday) junctions are accumulated in a RecG-dependent manner, arguing against the long-standing view that the redundancy of RuvAB and RecG is in the resolution of Holliday junctions. Using pulsed-field gel electrophoresis, we explain the redundancy by showing that branch migration catalysed by RuvAB and RecG is required for stabilising the intermediates of repair as, when branch migration cannot take place, repair is aborted and DNA is lost at the break locus. We demonstrate that in the repair of correctly aligned sister chromosomes, an unstable early intermediate is stabilised by branch migration. This reliance on branch migration may have evolved to help promote recombination between correctly aligned sister chromosomes to prevent genomic rearrangements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.