ReviewOrganogenesis
Liver bioengineering: from the stage of liver decellularized matrix to the multiple cellular actors and bioreactor special effects.
Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Isolation, characterization, and vascular potential of porcine cells in a three-dimensional decellularized liver matrix model.Frontiers in bioengineering and biotechnology · 2025Article
- Review
- Current Challenges and Future Promise for Use of Extracellular Matrix Scaffold to Achieve the Whole Organ Tissue Engineering Moonshot.Stem cells translational medicine · 2023Review
- Article
- Re-Endothelialization of Decellularized Liver Scaffolds: A Step for Bioengineered Liver Transplantation.Frontiers in bioengineering and biotechnology · 2022Review
- Opposite responses of normal hepatocytes and hepatocellular carcinoma cells to substrate viscoelasticity.Biomaterials science · 2020Article
- Induced Pluripotent Stem Cell-Derived Endothelial Cells: Overview, Current Advances, Applications, and Future Directions.The American journal of pathology · 2019Review
- Decellularized liver bioscaffold: a histological and immunohistochemical comparison between normal, fibrotic and hepatocellular carcinoma.Clinical and experimental hepatology · 2019Article
- Decellularised skeletal muscles allow functional muscle regeneration by promoting host cell migration.Scientific reports · 2018Article
- Heparin/Collagen 3D Scaffold Accelerates Hepatocyte Differentiation of Wharton's Jelly-Derived Mesenchymal Stem Cells.Tissue engineering and regenerative medicine · 2017Article
- Essential design considerations for the resazurin reduction assay to noninvasively quantify cell expansion within perfused extracellular matrix scaffolds.Biomaterials · 2017Article
- Xenogeneic Decellularized Scaffold: A Novel Platform for Ovary Regeneration.Tissue engineering. Part C, Methods · 2017Article
- Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases.BioMed research international · 2017Review
- Cell biology is different in small volumes: endogenous signals shape phenotype of primary hepatocytes cultured in microfluidic channels.Scientific reports · 2016Article
- Coming to terms with tissue engineering and regenerative medicine in the lung.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Strategies for improving the physiological relevance of human engineered tissues.Trends in biotechnology · 2015Review
- Emerging concepts in liver graft preservation.World journal of gastroenterology · 2015Review
- A review of cellularization strategies for tissue engineering of whole organs.Frontiers in bioengineering and biotechnology · 2015Review
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver bioengineering has been a field of intense research and popular excitement in the past decades. It experiences great interest since the introduction of whole liver acellular scaffolds generated by perfusion decellularization (1-3). Nevertheless, the different strategies developed so far have failed to generate hepatic tissue in vitro bioequivalent to native liver tissue. Even notable novel strategies that rely on iPSC-derived liver progenitor cells potential to self-organize in association with endothelial cells in hepatic organoids are lacking critical components of the native tissue (e.g., bile ducts, functional vascular network, hepatic microarchitecture, etc) (4). Hence, it is vital to understand the strengths and short comes of our current strategies in this quest to re-create liver organogenesis in vitro. To shed some light into these issues, this review describes the different actors that play crucial roles in liver organogenesis and highlights the steps still missing to successfully generate whole livers and hepatic organoids in vitro for multiple applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.