Evidence map›Paper›PMID 25102180›Full record

SynthesisPLoS genetics2014

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

Maggie C Y Ng, Daniel Shriner, Brian H Chen, Jiang Li, Wei-Min Chen, Xiuqing Guo, Jiankang Liu, Suzette J Bielinski, Lisa R Yanek, Michael A Nalls and 81 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

134 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  15. Genetic Variants inDiabetes · 2018
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74 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

91 authors.

Maggie C Y NgCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Daniel ShrinerCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Brian H ChenProgram on Genomics and Nutrition, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America; Center for Metabolic Disease Prevention, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America.
Jiang LiCenter for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Wei-Min ChenCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Jiankang LiuDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Suzette J BielinskiDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Lisa R YanekThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Michael A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Mary E ComeauCenter for Public Health Genomics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Laura J Rasmussen-TorvikDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Richard A JensenCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Daniel S EvansSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, United States of America.
Yan V SunDepartment of Epidemiology and Biomedical Informatics, Emory University, Atlanta, Georgia, United States of America.
Ping AnDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Sanjay R PatelDivision of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Loren L ArmstrongDivision of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Lynne WagenknechtDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Lingyao YangDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Beverly M SnivelyDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Nicholette D PalmerCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Poorva MudgalCenter for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Carl D LangefeldCenter for Public Health Genomics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Keith L KeeneDepartment of Biology, Center for Health Disparities, East Carolina University, Greenville, North Carolina, United States of America.
Barry I FreedmanDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Josyf C MychaleckyjCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America.
Uma NayakCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America.
Leslie J RaffelMedical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Mark O GoodarziMedical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Y-D Ida ChenInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Herman A TaylorDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America; Jackson State University, Tougaloo College, Jackson, Mississippi, United States of America.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Mario SimsDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
David CouperCollaborative Studies Coordinating Center, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Ayo DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Rasika A MathiasThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Division of Allergy and Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Dhananjay VaidyaThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Alan B ZondermanLaboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.
Robert P IgoDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
John R SedorDepartment of Medicine, Case Western Reserve University, MetroHealth System campus, Cleveland, Ohio, United States of America; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, United States of America.
FIND Consortium
Edmond K KabagambeDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
David S SiscovickCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America.
Barbara McKnightCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Kenneth RiceCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
Wen-Chi HsuehDepartment of Medicine, University of California, San Francisco, California, United States of America.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Aldi KrajaDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Michael A ProvinceDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee; International Epidemiology Institute, Rockville, Maryland, United States of America.
William L LoweDivision of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Jennifer A PachecoCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Dana C CrawfordCenter for Human Genetics Research and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.
eMERGE Consortium
DIAGRAM Consortium
Elin GrundbergDepartment of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
MuTHER Consortium
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America.
M Geoffrey HayesDivision of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Ingrid B BoreckiDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, United States of America.
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, United States of America.
Bruce M PsatyCardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Department of Epidemiology, University of Washington, Seattle, Washington, United States of America; Department of Health Services, University of Washington, Seattle, Washington, United States of America.
Myriam FornageHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
Sudha K IyengarDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, United States of America.
Michele K EvansHealth Disparities Unit, National Institute on Aging, National Institutes of Health, Baltimore Maryland, United States of America.
Diane M BeckerThe GeneSTAR Research Program, Division of General Internal Medicine, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
W H Linda KaoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Michèle M SaleCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America; Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America.
Simin LiuProgram on Genomics and Nutrition, School of Public Health, University of California Los Angeles, Los Angeles, California, United States of America; Department of Epidemiology, University of California Los Angeles, Los Angeles, California, United States of America; Departments of Epidemiology and Medicine, Brown University, Providence, Rhode Island, United States of America.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Donald W BowdenCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
MEta-analysis of type 2 DIabetes in African Americans Consortium

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAAS, RICHARD H · 1985 to 2010
$74.3M
ZONA-FREE HAMSTER OVA ASSAY AS AN INDICATOR OF MALE FERTILITYM01RR000425 · NCRR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ANDERSON, GAIL V · 1985 to 2011
$74.2M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)ZIAAG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$70.9M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
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UL1-RR-025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR025741NCRR NIH HHS UL1RR025741NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS T32 HG002536NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01 HG004599NHGRI NIH HHS U01 HG004603NHGRI NIH HHS U01 HG004608NHGRI NIH HHS U01-HG-004608NHGRI NIH HHS U01 HG004609NHGRI NIH HHS U01HG004609NHGRI NIH HHS U01 HG004610NHGRI NIH HHS U01-HG-004610NHGRI NIH HHS U01 HG006378NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01-HG-04599NHGRI NIH HHS Z01HG200362NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS HL047887NHLBI NIH HHS HL047889NHLBI NIH HHS HL047890NHLBI NIH HHS HL060894NHLBI NIH HHS HL060944NHLBI NIH HHS HL061210NHLBI NIH HHS HL071025-01A1NHLBI NIH HHS HL080295NHLBI NIH HHS HL085251NHLBI NIH HHS HL087652NHLBI NIH HHS HL087660NHLBI NIH HHS HL087698NHLBI NIH HHS HL100185NHLBI NIH HHS HL100245NHLBI NIH HHS HL103612NHLBI NIH HHS HL105756NHLBI NIH HHS HL120393NHLBI NIH HHS HL47902NHLBI NIH HHS HL58625-01A1NHLBI NIH HHS HL59684NHLBI NIH HHS HL62985NHLBI NIH HHS N01 HC005187NHLBI NIH HHS N01 HC045134NHLBI NIH HHS N01 HC045204NHLBI NIH HHS N01 HC045205NHLBI NIH HHS N01 HC048047NHLBI NIH HHS N01 HC048048NHLBI NIH HHS N01 HC048049NHLBI NIH HHS N01 HC048050NHLBI NIH HHS N01-HC-05187NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095095NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC-45134NHLBI NIH HHS N01-HC-45204NHLBI NIH HHS N01-HC-45205NHLBI NIH HHS N01-HC-48047NHLBI NIH HHS N01-HC-48049NHLBI NIH HHS N01-HC-48050NHLBI NIH HHS N01-HC-65226NHLBI NIH HHS N01-HC-95095NHLBI NIH HHS N01-HC-95100NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS N02-HL-6-4278NHLBI NIH HHS N02-HL-64278NHLBI NIH HHS NIH HL 46380NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL059684NHLBI NIH HHS R01 HL060894NHLBI NIH HHS R01 HL060944NHLBI NIH HHS R01 HL061210NHLBI NIH HHS R01 HL062985NHLBI NIH HHS R01 HL071025NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01-HL-071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01-HL-071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01-HL-071250NHLBI NIH HHS R01 HL071251NHLBI NIH HHS R01-HL-071251NHLBI NIH HHS R01 HL071252NHLBI NIH HHS R01-HL-071252NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01-HL-071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01-HL-071259NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL087698NHLBI NIH HHS R01 HL087700NHLBI NIH HHS R01-HL-087700NHLBI NIH HHS R01 HL088215NHLBI NIH HHS R01-HL-088215NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL56266NHLBI NIH HHS R01HL59367NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS RC1 HL100245NHLBI NIH HHS U01 HL047902NHLBI NIH HHS U01 HL072518NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01HL72518NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG023629NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG62101NIA NIH HHS N01AG62103NIA NIH HHS N01AG62106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIA NIH HHS Z01-AG000513NIDDK NIH HHS DK063491NIDDK NIH HHS DP3 DK094311NIDDK NIH HHS K99 DK081350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079637NIDDK NIH HHS R01 DK053591NIDDK NIH HHS R01 DK066358NIDDK NIH HHS R01 DK070941NIDDK NIH HHS R01 DK075681NIDDK NIH HHS R01-DK-075681NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK084350NIDDK NIH HHS R01-DK-8925601NIDDK NIH HHS U01 DK057249NIDDK NIH HHS U01DK057249NIDDK NIH HHS U01 DK057292NIDDK NIH HHS U01 DK057295NIDDK NIH HHS U01 DK057298NIDDK NIH HHS U01DK057298NIDDK NIH HHS U01 DK057300NIDDK NIH HHS U01DK057300NIDDK NIH HHS U01 DK057303NIDDK NIH HHS U01DK057303NIDDK NIH HHS U01 DK057304NIDDK NIH HHS U01 DK057329NIDDK NIH HHS U01 DK070657NIDDK NIH HHS U01DK070657NIDDK NIH HHS U01 DK078616NIDDK NIH HHS U01DK57292NIDDK NIH HHS U01DK57295NIDDK NIH HHS U01DK57304NIDDK NIH HHS U01DK57329NIGMS NIH HHS S06GM008016-320107NIGMS NIH HHS S06GM008016-380111NIMHD NIH HHS G12 MD007597NIMHD NIH HHS P20 MD006899NINDS NIH HHS U01 NS041588NINR NIH HHS NR0224103PHS HHS 24152PHS HHS 32100-2PHS HHS 32105-6PHS HHS 32108-9PHS HHS 32111-13PHS HHS 32115PHS HHS 32118PHS HHS 32119PHS HHS 32122PHS HHS 42107-26PHS HHS 42129-32PHS HHS 44221PHS HHS HHSC268200782096CPHS HHS HHSN268200625226CPHS HHS NHGRI T32-HG002536Wellcome Trust 098395WHI NIH HHS N01 WH022110WHI NIH HHS N01-WH-22110
6 · The paper itself

Abstract

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR)  = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.

Indexed as

Black or African AmericanDiabetes Mellitus, Type 2Genome-Wide Association StudyHLA-B27 AntigenHMGA2 ProteinHumansKCNQ1 Potassium ChannelMutant Chimeric ProteinsPolymorphism, Single NucleotideTranscription Factor 7-Like 2 ProteinHLA-B27 AntigenHLA-B protein, humanHMGA2 ProteinINS-IGF2 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanMutant Chimeric ProteinsTCF7L2 protein, humanTranscription Factor 7-Like 2 Protein

Identifiers

PMID25102180
PMCPMC4125087

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