ArticleThe Analyst2014
Detection of strep throat causing bacterium directly from medical swabs by touch spray-mass spectrometry.
Article in The Analyst, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Metabolite ratiomics: Rapid diagnosis and classification of gliomas for intraoperative application during brain surgery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Untargeted Swab Touch Spray-Mass Spectrometry Analysis with Machine Learning for On-Site Breast Surgical Margin Assessment.Analytical chemistry · 2025Article
- Universal, untargeted detection of bacteria in tissues using metabolomics workflows.Nature communications · 2025Article
- Influence of Solvent Relative Permittivity in Swab Spray Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- Analysis of Pesticide Residues on Fruit Using Swab Spray Ionization Mass Spectrometry.Molecules (Basel, Switzerland) · 2023Article
- Portable mass spectrometry system: instrumentation, applications, and path to 'omics analysis.Proteomics · 2022Review
- Identifying Clinically Relevant Bacteria Directly from Culture and Clinical Samples with a Handheld Mass Spectrometry Probe.Clinical chemistry · 2022Article
- CandyCollect: at-home saliva sampling for capture of respiratory pathogens.Lab on a chip · 2022Article
- Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication).Mass spectrometry (Tokyo, Japan) · 2021Article
- Novel Image Processing Method for Detecting Strep Throat (Streptococcal Pharyngitis) Using Smartphone.Sensors (Basel, Switzerland) · 2019Article
- Utilisation of Ambient Laser Desorption Ionisation Mass Spectrometry (ALDI-MS) Improves Lipid-Based Microbial Species Level Identification.Scientific reports · 2019Article
- Direct sampling mass spectrometry for clinical analysis.The Analyst · 2019Review
- Fatty Acid Patterns Detected By Ambient Ionization Mass Spectrometry in Canine Invasive Urothelial Carcinoma From Dogs of Different Breeds.Bladder cancer (Amsterdam, Netherlands) · 2018Article
- Precursor and Neutral Loss Scans in an RF Scanning Linear Quadrupole Ion Trap.Journal of the American Society for Mass Spectrometry · 2018Article
- Analysis of human gliomas by swab touch spray-mass spectrometry: applications to intraoperative assessment of surgical margins and presence of oncometabolites.The Analyst · 2017Article
- Ambient mass spectrometry in metabolomics.The Analyst · 2017Review
- Calling all hosts: Bacterial communicationChem · 2017Article
- Clinical Application of Ambient Ionization Mass Spectrometry.Mass spectrometry (Tokyo, Japan) · 2017Article
- Compatibility of Spatially Coded Apertures with a Miniature Mattauch-Herzog Mass Spectrograph.Journal of the American Society for Mass Spectrometry · 2016Article
- Ambient Mass Spectrometry Imaging Using Direct Liquid Extraction Techniques.Analytical chemistry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Strep throat causing Streptococcus pyogenes was detected in vitro and in simulated clinical samples by performing touch spray ionization-mass spectrometry. MS analysis took only seconds to reveal characteristic bacterial and human lipids. Medical swabs were used as the substrate for ambient ionization. This work constitutes the initial step in developing a non-invasive MS-based test for clinical diagnosis of strep throat. It is limited to the single species, S. pyogenes, which is responsible for the vast majority of cases. The method is complementary to and, with further testing, a potential alternative to current methods of point-of-care detection of S. pyogenes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.