ArticlePLoS genetics2014
The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Effects of Zymosan on Short-Chain Fatty Acid and Gas Production inFrontiers in nutrition · 2022Article
- High COAmerican journal of respiratory cell and molecular biology · 2020Article
- Optical silencing of body wall muscles induces pumping inhibition in Caenorhabditis elegans.PLoS genetics · 2017Article
- Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans.Scientific reports · 2017Article
- Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contraction of the pharynx muscles in Caenorhabditis elegans. To uncover the molecular mechanisms underlying this response, we performed a forward genetic screen and found that hid-1, a key component in neuropeptide signaling, regulates this inhibition in muscle contraction. Surprisingly, we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing. In addition, animals with mutations in unc-31 and egl-21 (neuropeptide secretion and maturation components) show impaired inhibition of muscle contraction following acute exposure to high CO2 levels, in further support of our findings. Interestingly, the observed response in the pharynx muscle requires the BAG neurons, which also mediate CO2 avoidance. This novel hid-1-mediated pathway sheds new light on the physiological effects of high CO2 levels on animals at the organism-wide level.
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Registered trials
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