Evidence map›Paper›PMID 25101328›Full record

ArticleProceedings of the ... International Symposium on High Performance Distributed Computing2010

Modeling sequence and function similarity between proteins for protein functional annotation.

Roger Higdon, Brenton Louie, Eugene Kolker

Abstract read
In one paragraph

Article in Proceedings of the ... International Symposium on High Performance Distributed Computing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Whole-Genome Sequencing ofMicroorganisms · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roger HigdonSeattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, roger.higdon@seattlechildrens.org.
Brenton LouieSeattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, brenton.louie@seattlechildrens.org.
Eugene KolkerSeattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, eugene.kolker@seattlechildrens.org.

Funding

Coordinating Center for Beta Cell Biology ConsortiumU01DK072473 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2005 to 2014
$61.0M
Experimental Standards and Computational Platform for HTP ProteomicsR01GM076680 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI KOLKER, EUGENE · 2006 to 2009
$1.7M
NIDDK NIH HHS U01 DK072473NIGMS NIH HHS R01 GM076680
6 · The paper itself

Abstract

A common task in biological research is to predict function for proteins by comparing sequences between proteins of known and unknown function. This is often done using pair-wise sequence alignment algorithms (e.g. BLAST). A problem with this approach is the assumption of a simple equivalence between a minimum sequence similarity threshold and the

Indexed as

BioinformaticsBiostatisticsExperimentationMultiple Sequence Alignment

Identifiers

PMID25101328
PMCPMC4120521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.