Evidence map›Paper›PMID 25101298›Full record

ReviewBioMed research international2014

Drug delivery nanoparticles in skin cancers.

Chiara Dianzani, Gian Paolo Zara, Giovanni Maina, Piergiorgio Pettazzoni, Stefania Pizzimenti, Federica Rossi, Casimiro Luca Gigliotti, Eric Stefano Ciamporcero, Martina Daga, Giuseppina Barrera

Erratum issuedAbstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Chiara DianzaniDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Gian Paolo ZaraDepartment of Drug Science and Technology, University of Turin, 10125 Turin, Italy.
Giovanni MainaDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Piergiorgio PettazzoniDepartment of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Stefania PizzimentiDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Federica RossiDepartment of Public and Pediatric Health Sciences, University of Turin, 10126 Turin, Italy.
Casimiro Luca GigliottiDepartment of Health Sciences, University of Eastern Piedmont "Amedeo Avogadro," 28100 Novara, Italy.
Eric Stefano CiamporceroDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Martina DagaDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.
Giuseppina BarreraDepartment of Clinical and Biological Sciences, University of Turin, 10125 Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanotechnology involves the engineering of functional systems at nanoscale, thus being attractive for disciplines ranging from materials science to biomedicine. One of the most active research areas of the nanotechnology is nanomedicine, which applies nanotechnology to highly specific medical interventions for prevention, diagnosis, and treatment of diseases, including cancer disease. Over the past two decades, the rapid developments in nanotechnology have allowed the incorporation of multiple therapeutic, sensing, and targeting agents into nanoparticles, for detection, prevention, and treatment of cancer diseases. Nanoparticles offer many advantages as drug carrier systems since they can improve the solubility of poorly water-soluble drugs, modify pharmacokinetics, increase drug half-life by reducing immunogenicity, improve bioavailability, and diminish drug metabolism. They can also enable a tunable release of therapeutic compounds and the simultaneous delivery of two or more drugs for combination therapy. In this review, we discuss the recent advances in the use of different types of nanoparticles for systemic and topical drug delivery in the treatment of skin cancer. In particular, the progress in the treatment with nanocarriers of basal cell carcinoma, squamous cell carcinoma, and melanoma has been reported.

Indexed as

Drug Delivery SystemsBasal Cell CarcinomaCarcinoma, Squamous CellDrug CarriersHumansMelanomaNanoparticlesSkin NeoplasmsDrug Carriers

Identifiers

PMID25101298
PMCPMC4102061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.