ReviewFrontiers in psychology2014
Compulsivity in anorexia nervosa: a transdiagnostic concept.
Review in Frontiers in psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02794389 (How do Glutathione Levels Affect Compulsivity? A Double-blind, Placebo-controlled Study), which is not on this map. Cited by 71 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
How do Glutathione Levels Affect Compulsivity? A Double-blind, Placebo-controlled Study
Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Morbid exercise behaviour and eating disorders: A meta-analysis.Journal of behavioral addictions · 2020Pooled it
- Cognitive remediation therapy (CRT) as a treatment enhancer of eating disorders and obsessive compulsive disorders: study protocol for a randomized controlled trial.BMC psychiatry · 2016Trial
- A Randomised Controlled Trial of Neuronavigated Repetitive Transcranial Magnetic Stimulation (rTMS) in Anorexia Nervosa.PloS one · 2016Trial
- Glucocorticoid signalling dysregulation and immune cell adaptation in Anorexia Nervosa.Molecular psychiatry · 2026Article
- Naturalistic Associations Between Childhood Maltreatment, Compulsivity, and Eating Disorder Symptoms Over a 12-Months Period Among Individuals With Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2026Article
- Intertemporal Pavlovian biases and links with mental health in the general population.Cognitive, affective & behavioral neuroscience · 2025Article
- Overlapping Spectrum of Impulsivity and Compulsivity Across Psychiatric Disorders: A Narrative Review on Dimensional Perspectives.The Eurasian journal of medicine · 2025Article
- Nucleus accumbens deep brain stimulation in adult patients suffering from severe and enduring anorexia nervosa (STIMARS): protocol for a pilot study.Frontiers in psychiatry · 2025Article
- Reward responsivity and habit formation in the co-occurrence of restrictive eating and nonsuicidal self-injury.Journal of psychiatric research · 2024Article
- Article
- Corpus callosum morphology and relationships to illness phenotypes in individuals with anorexia nervosa.Scientific reports · 2024Article
- The Efficacy of Cognitive Remediation Therapy for Anorexia Nervosa: A Systematic Review of Systematic Reviews.Brain sciences · 2024Review
- To eat or not to eat: A role for ghrelin and LEAP2 in eating disorders?Neuroscience applied · 2024Review
- Remediating cognitive inflexibility in obsessive compulsive disorder and anorexia nervosa neither moderates nor mediates treatment effects: an exploratory study.Frontiers in psychiatry · 2024Article
- Adaptive learning from outcome contingencies in eating-disorder risk groups.Translational psychiatry · 2023Article
- Habits and Persistent Food Restriction in Patients with Anorexia Nervosa: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2023Article
- Eating disorder symptoms and control-seeking behavior.Brain and behavior · 2023Article
- The absence of association between anorexia nervosa and smoking: converging evidence across two studies.European child & adolescent psychiatry · 2023Article
- Food Restriction in Anorexia Nervosa in the Light of Modern Learning Theory: A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2023Review
- The Treatment Experience of Anorexia Nervosa in Adolescents from Healthcare Professionals' Perspective: A Qualitative Study.International journal of environmental research and public health · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The compulsive nature of weight loss behaviors central to anorexia nervosa (AN), such as relentless self-starvation and over-exercise, has led to the suggestion of parallels between AN and other compulsive disorders such as obsessive-compulsive disorder (OCD) and addictions. There is a huge unmet need for effective treatments in AN, which has high rates of morbidity and the highest mortality rate of any psychiatric disorder, yet a grave paucity of effective treatments. Viewing compulsivity as a transdiagnostic concept, seen in various manifestations across disorders, may help delineate the mechanisms responsible for the persistence of AN, and aid treatment development. We explore models of compulsivity that suggest dysfunction in cortico-striatal circuitry underpins compulsive behavior, and consider evidence of aberrancies in this circuitry across disorders. Excessive habit formation is considered as a mechanism by which initially rewarding weight loss behavior in AN may become compulsive over time, and the complex balance between positive and negative reinforcement in this process is considered. The physiological effects of starvation in promoting compulsivity, positive reinforcement, and habit formation are also discussed. Further research in AN may benefit from a focus on processes potentially underlying the development of compulsivity, such as aberrant reward processing and habit formation. We discuss the implications of a transdiagnostic perspective on compulsivity, and how it may contribute to the development of novel treatments for AN.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.