Evidence map›Paper›PMID 25101009›Full record

ArticleFrontiers in psychiatry2014

Time Course of Corticospinal Excitability and Autonomic Function Interplay during and Following Monopolar tDCS.

Emiliano Santarnecchi, Matteo Feurra, Federico Barneschi, Maurizio Acampa, Giovanni Bianco, David Cioncoloni, Alessandro Rossi, Simone Rossi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Effects of transcranial direct current stimulation on motor function in patients with multiple sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  2. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
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  4. Does M1 anodal transcranial direct current stimulation affects online and offline motor learning in patients with multiple sclerosis?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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  18. Thalamic altered spontaneous activity and connectivity in obstructive sleep apnea syndrome.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emiliano SantarnecchiUnit of Neurology and Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena , Italy ; Brain Investigation and Neuromodulation Lab, University of Siena , Siena , Italy.
Matteo FeurraUnit of Neurology and Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena , Italy ; Brain Investigation and Neuromodulation Lab, University of Siena , Siena , Italy.
Federico BarneschiBrain Investigation and Neuromodulation Lab, University of Siena , Siena , Italy.
Maurizio AcampaU.O.C. Stroke Unit, Department of Medicine, Surgery and Neuroscience, Le Scotte Policlinic , Siena , Italy.
Giovanni BiancoBrain Investigation and Neuromodulation Lab, University of Siena , Siena , Italy.
David CioncoloniUnit of Neurology and Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena , Italy ; Brain Investigation and Neuromodulation Lab, University of Siena , Siena , Italy.
Alessandro RossiUnit of Neurology and Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena , Italy.
Simone RossiUnit of Neurology and Neurophysiology, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena , Italy ; Brain Investigation and Neuromodulation Lab, University of Siena , Siena , Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While polarity-specific after-effects of monopolar transcranial direct current stimulation (tDCS) on corticospinal excitability are well-documented, modulation of vital parameters due to current spread through the brainstem is still a matter of debate, raising potential concerns about its use through the general public, as well as for neurorehabilitation purposes. We monitored online and after-effects of monopolar tDCS (primary motor cortex) in 10 healthy subjects by adopting a neuronavigated transcranial magnetic stimulation (TMS)/tDCS combined protocol. Motor evoked potentials (MEPs) together with vital parameters [e.g., blood pressure, heart-rate variability (HRV), and sympathovagal balance] were recorded and monitored before, during, and after anodal, cathodal, or sham tDCS. Ten MEPs, every 2.5-min time windows, were recorded from the right first dorsal interosseous (FDI), while 5-min epochs were used to record vital parameters. The protocol included 15 min of pre-tDCS and of online tDCS (anodal, cathodal, or sham). After-effects were recorded for 30 min. We showed a polarity-independent stabilization of cortical excitability level, a polarity-specific after-effect for cathodal and anodal stimulation, and an absence of persistent excitability changes during online stimulation. No significant effects on vital parameters emerged both during and after tDCS, while a linear increase in systolic/diastolic blood pressure and HRV was observed during each tDCS condition, as a possible unspecific response to experimental demands. Taken together, current findings provide new insights on the safety of monopolar tDCS, promoting its application both in research and clinical settings.

Indexed as

neuromodulationsafetytranscranial direct current stimulationtranscranial magnetic stimulationvital parameters

Identifiers

PMID25101009
PMCPMC4104833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.