ArticleFrontiers in neuroengineering2014
Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects.
Article in Frontiers in neuroengineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02983370 (Pilot Study for the Development of a Cortical Visual Neuroprosthesis for the Blind Based on Intracortical Microelectrodes), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study for the Development of a Cortical Visual Neuroprosthesis for the Blind Based on Intracortical Microelectrodes
Who cites it
40 citing papers in PubMed, 136 citations in OpenAlex.
- Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array.Nature communications · 2026Article
- Intracortical microstimulation induces rapid microglia process convergence.Biomaterials · 2026Article
- From synthetic vesicles to living cells: Anchoring conducting polymers to cell membrane.Science advances · 2024Article
- An optrode array for spatiotemporally-precise large-scale optogenetic stimulation of deep cortical layers in non-human primates.Communications biology · 2024Article
- Glial scarring around intra-cortical MEA implants with flexible and free microwires inserted using biodegradable PLGA needles.Frontiers in bioengineering and biotechnology · 2024Article
- Selective Immunosuppression Targeting the NLRP3 Inflammasome Mitigates the Foreign Body Response to Implanted Biomaterials While Preserving Angiogenesis.Advanced healthcare materials · 2023Article
- Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring.Cell reports · 2023Article
- Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes.ACS applied bio materials · 2023Article
- Cortical Ripples during NREM Sleep and Waking in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Semi-Implantable Bioelectronics.Nano-micro letters · 2022Review
- Poly(3,4-ethylenedioxythiophene)-Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Vision Restoration by Optogenetic Therapy and Developments Toward Sonogenetic Therapy.Translational vision science & technology · 2022Article
- Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.Brain communications · 2022Article
- Biofabrication of a Low Modulus Bioelectroprobe for Neurons to Grow Into.Materials (Basel, Switzerland) · 2021Article
- Longitudinal analysis of local field potentials recorded from directional deep brain stimulation lead implants in the subthalamic nucleus.Journal of neural engineering · 2021Article
- Advanced real-time recordings of neuronal activity with tailored patch pipettes, diamond multi-electrode arrays and electrochromic voltage-sensitive dyes.Pflugers Archiv : European journal of physiology · 2021Review
- Host tissue response to floating microelectrode arrays chronically implanted in the feline spinal nerve.Journal of neural engineering · 2020Article
- Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation.Acta biomaterialia · 2020Article
- Inhibition of Long-Term Variability in Decoding Forelimb Trajectory Using Evolutionary Neural Networks With Error-Correction Learning.Frontiers in computational neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emerging field of neuroprosthetics is focused on the development of new therapeutic interventions that will be able to restore some lost neural function by selective electrical stimulation or by harnessing activity recorded from populations of neurons. As more and more patients benefit from these approaches, the interest in neural interfaces has grown significantly and a new generation of penetrating microelectrode arrays are providing unprecedented access to the neurons of the central nervous system (CNS). These microelectrodes have active tip dimensions that are similar in size to neurons and because they penetrate the nervous system, they provide selective access to these cells (within a few microns). However, the very long-term viability of chronically implanted microelectrodes and the capability of recording the same spiking activity over long time periods still remain to be established and confirmed in human studies. Here we review the main responses to acute implantation of microelectrode arrays, and emphasize that it will become essential to control the neural tissue damage induced by these intracortical microelectrodes in order to achieve the high clinical potentials accompanying this technology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.