ArticleFrontiers in behavioral neuroscience2014
5-HTTLPR modulates the recognition accuracy and exploration of emotional facial expressions.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Visual attention toward emotional stimuli: Anxiety symptoms correspond to distinct gaze patterns.PloS one · 2021Trial
- Facial features associated with fear and happiness attract gaze during brief exposure without enhancing emotion recognition.Scientific reports · 2025Article
- Can Perceivers Differentiate Intense Facial Expressions? Eye Movement Patterns.Behavioral sciences (Basel, Switzerland) · 2024Article
- An eye-tracking study of interpersonal threat sensitivity and adverse childhood experiences in borderline personality disorder.Borderline personality disorder and emotion dysregulation · 2021Article
- Article
- Foveal processing of emotion-informative facial features.PloS one · 2021Article
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- The genetics of anxiety-related negative valence system traits.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Preferential Processing of Social Features and Their Interplay with Physical Saliency in Complex Naturalistic Scenes.Frontiers in psychology · 2017Article
- Attentional mechanisms of social perception are biased in social phobia.Journal of anxiety disorders · 2016Article
- Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture.Biology letters · 2016Article
- BDNF Val(66)Met and 5-HTTLPR Genotype are Each Associated with Visual Scanning Patterns of Faces in Young Children.Frontiers in behavioral neuroscience · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual genetic differences in the serotonin transporter-linked polymorphic region (5-HTTLPR) have been associated with variations in the sensitivity to social and emotional cues as well as altered amygdala reactivity to facial expressions of emotion. Amygdala activation has further been shown to trigger gaze changes toward diagnostically relevant facial features. The current study examined whether altered socio-emotional reactivity in variants of the 5-HTTLPR promoter polymorphism reflects individual differences in attending to diagnostic features of facial expressions. For this purpose, visual exploration of emotional facial expressions was compared between a low (n = 39) and a high (n = 40) 5-HTT expressing group of healthy human volunteers in an eye tracking paradigm. Emotional faces were presented while manipulating the initial fixation such that saccadic changes toward the eyes and toward the mouth could be identified. We found that the low vs. the high 5-HTT group demonstrated greater accuracy with regard to emotion classifications, particularly when faces were presented for a longer duration. No group differences in gaze orientation toward diagnostic facial features could be observed. However, participants in the low 5-HTT group exhibited more and faster fixation changes for certain emotions when faces were presented for a longer duration and overall face fixation times were reduced for this genotype group. These results suggest that the 5-HTT gene influences social perception by modulating the general vigilance to social cues rather than selectively affecting the pre-attentive detection of diagnostic facial features.
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