ArticleFrontiers in cellular neuroscience2014
Dendritic diameters affect the spatial variability of intracellular calcium dynamics in computer models.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Spatial characterization of backpropagating action potential-evoked CaFrontiers in synaptic neuroscience · 2026Article
- Vesicle and reaction-diffusion hybrid modeling with STEPS.Communications biology · 2024Article
- Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity.Communications biology · 2024Article
- Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024Review
- Topology recapitulates morphogenesis of neuronal dendrites.Cell reports · 2023Article
- Synaptic Plasticity Is Predicted by Spatiotemporal Firing Rate Patterns and Robust to In Vivo-like Variability.Biomolecules · 2022Article
- STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale.Frontiers in neuroinformatics · 2022Article
- Modeling Neurons in 3D at the Nanoscale.Advances in experimental medicine and biology · 2022Article
- Prediction of Neural Diameter From Morphology to Enable Accurate Simulation.Frontiers in neuroinformatics · 2021Article
- NeuroPath2Path: Classification and elastic morphing between neuronal arbors using path-wise similarity.Neuroinformatics · 2020Article
- Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation.Cerebral cortex communications · 2020Article
- Two Distinct Sets of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- ShuTu: Open-Source Software for Efficient and Accurate Reconstruction of Dendritic Morphology.Frontiers in neuroinformatics · 2019Article
- Article
- Simultaneous dendritic voltage and calcium imaging and somatic recording from Purkinje neurons in awake mice.Nature communications · 2018Article
- Mechanisms of Supralinear Calcium Integration in Dendrites of Hippocampal CA1 Fast-Spiking Cells.Frontiers in synaptic neuroscience · 2018Article
- Article
- Synaptic Activation of a Detailed Purkinje Cell Model Predicts Voltage-Dependent Control of Burst-Pause Responses in Active Dendrites.Frontiers in cellular neuroscience · 2017Article
- Calcium Dynamics in Basal Dendrites of Layer 5A and 5B Pyramidal Neurons Is Tuned to the Cell-Type Specific Physiological Action Potential Discharge.Frontiers in cellular neuroscience · 2017Article
- Parallel STEPS: Large Scale Stochastic Spatial Reaction-Diffusion Simulation with High Performance Computers.Frontiers in neuroinformatics · 2017Article
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6 authors.
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Abstract
There is growing interest in understanding calcium dynamics in dendrites, both experimentally and computationally. Many processes influence these dynamics, but in dendrites there is a strong contribution of morphology because the peak calcium levels are strongly determined by the surface to volume ratio (SVR) of each branch, which is inversely related to branch diameter. In this study we explore the predicted variance of dendritic calcium concentrations due to local changes in dendrite diameter and how this is affected by the modeling approach used. We investigate this in a model of dendritic calcium spiking in different reconstructions of cerebellar Purkinje cells and in morphological analysis of neocortical and hippocampal pyramidal neurons. We report that many published models neglect diameter-dependent effects on calcium concentration and show how to implement this correctly in the NEURON simulator, both for phenomenological pool based models and for implementations using radial 1D diffusion. More detailed modeling requires simulation of 3D diffusion and we demonstrate that this does not dissipate the local concentration variance due to changes of dendritic diameter. In many cases 1D diffusion of models of calcium buffering give a good approximation provided an increased morphological resolution is implemented.
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