ArticleGeburtshilfe und Frauenheilkunde2014
Overweight and Obesity before, during and after Pregnancy: Part 1: Pathophysiology, Molecular Biology and Epigenetic Consequences.
Article in Geburtshilfe und Frauenheilkunde, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Antepartum Care of Women Who Are Obese During Pregnancy: Systematic Review of the Current Evidence.Journal of midwifery & women's health · 2018Pooled it
- Serum level and polymorphisms of retinol-binding protein-4 and risk for gestational diabetes mellitus: a meta-analysis.BMC pregnancy and childbirth · 2016Pooled it
- Reduction of Neonatal Macrosomia Rate of Infants Born to Overweight and Obese Women through Nutrition Counseling in Pregnancy - A One-arm Interventional Study.Geburtshilfe und Frauenheilkunde · 2025Article
- Managing obstetric and gynecologic complications in obese women: Evidence-Based Strategies for Optimizing Outcomes and Reducing Risks.Annals of medicine and surgery (2012) · 2025Review
- Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells.Experimental & molecular medicine · 2023Article
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- Leptin gene polymorphism (rs7799039; G2548A) is associated with changes in serum lipid concentrations during pregnancy: a prospective cohort study.European journal of nutrition · 2020Article
- Changes in Maternal Body Mass Index, Weight Gain and Outcome of Singleton Pregnancies from 2000 to 2015: A Population-based Retrospective Cohort Study in Hesse/Germany.Geburtshilfe und Frauenheilkunde · 2020Article
- Association of polymorphisms in STRA6 gene with gestational diabetes mellitus in a Chinese Han population.Medicine · 2019Article
- Replication of previous genome-wide association studies ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- A qualitative study exploring midwives' perceptions and knowledge of maternal obesity: Reflecting on their experiences of providing healthy eating and weight management advice to pregnant women.Maternal & child nutrition · 2018Article
- Increasing prevalence of overweight and obesity in Bangladeshi women of reproductive age: Findings from 2004 to 2014.PloS one · 2017Article
- Pregnancy: An Underutilized Window of Opportunity to Improve Long-term Maternal and Infant Health-An Appeal for Continuous Family Care and Interdisciplinary Communication.Frontiers in pediatrics · 2017Review
- Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development.Frontiers in pediatrics · 2017Review
- Obesity and cancer: the role of adipose tissue and adipo-cytokines-induced chronic inflammation.Journal of Cancer · 2016Review
- Maternal and Fetal Lipid and Adipokine Profiles and Their Association with Obesity.International journal of endocrinology · 2016Article
- Obesity and Maternal Weight Gain.Current obesity reports · 2015Article
- Experimental gestational diabetes mellitus induces blunted vasoconstriction and functional changes in the rat aorta.BioMed research international · 2014Article
- Association of Leptin and Retinol Binding Protein 4 with the Risk of Gestational Diabetes: A Systematic Review and Meta-Analysis of Observational Studies.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overweight and obesity before conception as well as excessive weight gain during pregnancy are associated with endocrinological changes of mother and fetus. Insulin resistance physiologically increases during pregnancy, additional obesity further increases insulin resistance. In combination with reduced insulin secretion this leads to gestational diabetes which may develop into type-2-diabetes. The adipose tissue produces TNF-alpha, interleukins and leptin and upregulates these adipokines. Insulin resistance and obesity induce inflammatory processes and vascular dysfunction, which explains the increased rate of pregnancy-related hypertension and pre-eclampsia in obese pregnant women. Between 14 and 28 gestational weeks, the fetal adipose tissue is generated and the number of fat lobules is determined. Thereafter, an increase in adipose tissue is arranged by an enlargement of the lobules (hypertrophy), or even an increase in the number of fat cells (hyperplasia). Human and animal studies have shown that maternal obesity "programmes" the offspring for further obesity and chronic disease. Pregnant women, midwives, physicians and health care politicians should be better informed about prevention, pathophysiological mechanisms, and the burden for society caused by obesity before, during and after pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.