ArticleMolecular biology and evolution2014
Improved calibration of the human mitochondrial clock using ancient genomes.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 126 citations in OpenAlex.
- Review
- Revisiting the African mtDNA landscape through complete mitochondrial genomes.Communications biology · 2026Article
- Analysis of Selective Pressure on Ancient Human Mitochondrial Genomes Reveals the Presence of Widespread Sequencing Artefacts.International journal of molecular sciences · 2025Article
- Convergent Mutations and Single Nucleotide Variants in Mitochondrial Genomes of Modern Humans and Neanderthals.International journal of molecular sciences · 2024Article
- Dating ancient splits in phylogenetic trees, with application to the human-Neanderthal split.BMC genomic data · 2024Article
- Relationships of Late Pleistocene giant deer as revealed byiScience · 2023Article
- North and East African mitochondrial genetic variation needs further characterization towards precision medicine.Journal of advanced research · 2023Article
- Unraveling the mitochondrial phylogenetic landscape of Thailand reveals complex admixture and demographic dynamics.Scientific reports · 2023Article
- Mitogenome analysis reveals predominantly ancient Yellow River origin of population inhabiting Datong agro-pastoral ecotone along Great Wall.Molecular genetics and genomics : MGG · 2023Article
- Review
- Herbarium specimen sequencing allows precise dating of Xanthomonas citri pv. citri diversification history.Nature communications · 2023Article
- Museum specimens of a landlocked pinniped reveal recent loss of genetic diversity and unexpected population connections.Ecology and evolution · 2023Article
- Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave.Communications biology · 2022Article
- Variation in the Substitution Rates among the Human Mitochondrial Haplogroup U Sublineages.Genome biology and evolution · 2022Article
- African mitochondrial haplogroup L7: a 100,000-year-old maternal human lineage discovered through reassessment and new sequencing.Scientific reports · 2022Article
- Pedigree derived mutation rate across the entire mitochondrial genome of the Norfolk Island population.Scientific reports · 2022Article
- Simulated patterns of mitochondrial diversity are consistent with partial population turnover in Bronze Age Central Europe.American journal of biological anthropology · 2022Article
- Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia.PloS one · 2022Article
- Article
- Genome-scale sequencing and analysis of human, wolf, and bison DNA from 25,000-year-old sediment.Current biology : CB · 2021Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Reliable estimates of the rate at which DNA accumulates mutations (the substitution rate) are crucial for our understanding of the evolution and past demography of virtually any species. In humans, there are considerable uncertainties around these rates, with substantial variation among recent published estimates. Substitution rates have traditionally been estimated by associating dated events to the root (e.g., the divergence between humans and chimpanzees) or to internal nodes in a phylogenetic tree (e.g., first entry into the Americas). The recent availability of ancient mitochondrial DNA sequences allows for a more direct calibration by assigning the age of the sequenced samples to the tips within the human phylogenetic tree. But studies also vary greatly in the methodology employed and in the sequence panels analyzed, making it difficult to tease apart the causes for the differences between previous estimates. To clarify this issue, we compiled a comprehensive data set of 350 ancient and modern human complete mitochondrial DNA genomes, among which 146 were generated for the purpose of this study and estimated substitution rates using calibrations based both on dated nodes and tips. Our results demonstrate that, for the same data set, estimates based on individual dated tips are far more consistent with each other than those based on nodes and should thus be considered as more reliable.
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